P-Selectin expression, platelet aggregates, and platelet-derived microparticle formation are increased in peripheral arterial disease
Platelet volume has been reported to be increased in vascular disease. Therefore, we studied the relationship of mean platelet volume and platelet count as well as flow cytometrically measured platelet size and platelet function in 50 patients with peripheral arterial disease and 50 healthy voluntee...
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Published in | Blood coagulation & fibrinolysis Vol. 11; no. 8; p. 723 |
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Main Authors | , , , , , |
Format | Journal Article |
Language | English |
Published |
England
01.12.2000
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Abstract | Platelet volume has been reported to be increased in vascular disease. Therefore, we studied the relationship of mean platelet volume and platelet count as well as flow cytometrically measured platelet size and platelet function in 50 patients with peripheral arterial disease and 50 healthy volunteers. Platelet activation was measured by P-selectin expression analysis on resting and on stimulated platelets, and the determination of platelet aggregates and platelet-derived microparticles using flow cytometry. P-Selectin expression on platelets was significantly elevated in patients suffering from peripheral arterial disease (all P<0.0001). Platelet aggregates (P<0.0001) and platelet-derived microparticles (P<0.0001) were significantly higher in the patient group compared with controls, whereas mean platelet volume and platelet count showed no significant differences. Platelet count was inversely related to mean platelet volume in patients and controls (r = -0.43, P<0.001). The present study supports the hypothesis of platelet hyperreactivity and circulating activated platelets in peripheral arterial disease. Mean platelet volume, and platelet count cannot be used as predictive markers for platelet activation in peripheral arterial disease patients. |
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AbstractList | Platelet volume has been reported to be increased in vascular disease. Therefore, we studied the relationship of mean platelet volume and platelet count as well as flow cytometrically measured platelet size and platelet function in 50 patients with peripheral arterial disease and 50 healthy volunteers. Platelet activation was measured by P-selectin expression analysis on resting and on stimulated platelets, and the determination of platelet aggregates and platelet-derived microparticles using flow cytometry. P-Selectin expression on platelets was significantly elevated in patients suffering from peripheral arterial disease (all P<0.0001). Platelet aggregates (P<0.0001) and platelet-derived microparticles (P<0.0001) were significantly higher in the patient group compared with controls, whereas mean platelet volume and platelet count showed no significant differences. Platelet count was inversely related to mean platelet volume in patients and controls (r = -0.43, P<0.001). The present study supports the hypothesis of platelet hyperreactivity and circulating activated platelets in peripheral arterial disease. Mean platelet volume, and platelet count cannot be used as predictive markers for platelet activation in peripheral arterial disease patients. |
Author | Stephan, S Koksch, M Pfeiffer, D Hoheisel, G Ruehlmann, C Zeiger, F |
Author_xml | – sequence: 1 givenname: F surname: Zeiger fullname: Zeiger, F email: zeif@medizin.uni-leipzig.de organization: Department of Internal Medicine, Cardiology/Angiology Unit, University of Leipzig, Germany. zeif@medizin.uni-leipzig.de – sequence: 2 givenname: S surname: Stephan fullname: Stephan, S – sequence: 3 givenname: G surname: Hoheisel fullname: Hoheisel, G – sequence: 4 givenname: D surname: Pfeiffer fullname: Pfeiffer, D – sequence: 5 givenname: C surname: Ruehlmann fullname: Ruehlmann, C – sequence: 6 givenname: M surname: Koksch fullname: Koksch, M |
BackLink | https://www.ncbi.nlm.nih.gov/pubmed/11132650$$D View this record in MEDLINE/PubMed |
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SubjectTerms | Adult Blood Platelets - pathology Blood Platelets - physiology Blood Platelets - ultrastructure Cytoplasmic Granules - physiology Cytoplasmic Granules - ultrastructure Humans Male Middle Aged P-Selectin - biosynthesis Peripheral Vascular Diseases - blood Peripheral Vascular Diseases - pathology Peripheral Vascular Diseases - physiopathology Platelet Aggregation Platelet Count |
Title | P-Selectin expression, platelet aggregates, and platelet-derived microparticle formation are increased in peripheral arterial disease |
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