Feasibility of nonselective testing for hemoglobinopathies in early pregnancy in The Netherlands

• Published in: Prenatal diagnosis Vol. 31; no. 13; pp. 1259 - 1263
• Main Authors: Kaufmann, Judith O., Demirel-Güngör, Gönül, Selles, Anke, Hudig, Cisca, Steen, Gerard, Ponjee, Gabrielle, Holleboom, Cas, Freeman, Liv M., Hendiks, Joris, Wijermans, Pierre, Giordano, Piero C., Kerkhoffs, Jean-Louis
• Format: Journal Article
• Language: English
• Published: Chichester, UK John Wiley & Sons, Ltd 01.12.2011; Wiley
• Subjects: Adolescent; Adult; beta-Globins - genetics; Biological and medical sciences; Chromatography, High Pressure Liquid; Delivery. Postpartum. Lactation; ethnic minorities; Feasibility Studies; Female; Fundamental and applied biological sciences. Psychology; Genetic Testing; Genetics of eukaryotes. Biological and molecular evolution; Gynecology. Andrology. Obstetrics; Hematologic Tests; hemoglobinopathies; Hemoglobinopathies - blood; Hemoglobinopathies - diagnosis; Hemoglobinopathies - epidemiology; Hemoglobinopathies - genetics; Hemoglobins, Abnormal - genetics; Heterozygote; Humans; Medical sciences; Molecular and cellular biology; Netherlands - epidemiology; Polymerase Chain Reaction; Pregnancy; Pregnancy Complications, Hematologic - blood; Pregnancy Complications, Hematologic - diagnosis; Pregnancy Complications, Hematologic - epidemiology; Pregnancy Complications, Hematologic - genetics; Pregnancy Trimester, First; prenatal diagnosis; Prenatal Diagnosis - methods; prevention; Prospective Studies; Retrospective Studies; thalassemia; Young Adult; Netherlands; Europe; Hemoglobinopathy; hemoglobinopathies; Gynecology; Neonatology; Thalassemia; Hemopathy; Epidemiology; ethnic minorities; Ethnic group; Genetic disease; Prevention; Hemolytic anemia; Prenatal diagnosis; Early pregnancy; Genetics; Feasibility

Objective To examine the feasibility of standardized hemoglobinopathy (HBP) carrier testing for pregnant women in The Netherlands in addition to the standard anemia screening. Methods We assessed the prevalence of HBP in women at the time of the first pregnancy visit using both a prospective cohort...