The β3-adrenergic receptor agonist mirabegron improves glucose homeostasis in obese humans

• Published in: The Journal of clinical investigation Vol. 130; no. 5; pp. 2319 - 2331
• Main Authors: Finlin, Brian S., Memetimin, Hasiyet, Zhu, Beibei, Confides, Amy L., Vekaria, Hemendra J., El Khouli, Riham H., Johnson, Zachary R., Westgate, Philip M., Chen, Jianzhong, Morris, Andrew J., Sullivan, Patrick G., Dupont-Versteegden, Esther E., Kern, Philip A.
• Format: Journal Article
• Language: English
• Published: United States American Society for Clinical Investigation 01.05.2020
• Subjects: Acetanilides - administration & dosage; Adipocytes; Adipocytes - metabolism; Adipocytes - pathology; Adipose tissue (brown); Adipose Tissue, Beige - metabolism; Adipose Tissue, Beige - pathology; Adrenergic beta-3 Receptor Agonists - administration & dosage; Adrenergic receptors; Adult; Aged; Agonists; Biomedical research; Biopsy; Blood Glucose - metabolism; Clinical Medicine; Cold; Diabetes; Female; Gene expression; Gene Expression Regulation - drug effects; Glucose; Glucose tolerance; Hemoglobin; Homeostasis; Humans; Insulin; Insulin resistance; Lipids; Lipolysis; Macrophages; Male; Metabolism; Middle Aged; Muscle, Skeletal - metabolism; Muscle, Skeletal - pathology; Musculoskeletal system; Nervous system; Obesity; Obesity - blood; Obesity - drug therapy; Obesity - pathology; Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha - biosynthesis; Skeletal muscle; Thermogenesis; Thiazoles - administration & dosage; Triglycerides; Weight control; Glucose metabolism; Obesity; Adipose tissue; Metabolism; Clinical Trials

BACKGROUNDBeige adipose tissue is associated with improved glucose homeostasis in mice. Adipose tissue contains β3-adrenergic receptors (β3-ARs), and this study was intended to determine whether the treatment of obese, insulin-resistant humans with the β3-AR agonist mirabegron, which stimulates beig...