Hemangioma in the newborn: increased incidence after chorionic villus sampling

• Published in: Prenatal diagnosis Vol. 30; no. 10; pp. 913 - 917
• Main Authors: Bauland, Constantijn G., Smit, Jeroen M., Bartelink, Lidewij R., Zondervan, Hans A., Spauwen, Paul H. M.
• Format: Journal Article
• Language: English
• Published: Chichester, UK John Wiley & Sons, Ltd 01.10.2010; Wiley
• Subjects: amniocentesis; Amniocentesis - adverse effects; Biological and medical sciences; Chorionic Villi Sampling - adverse effects; chorionic villus sampling; Cohort Studies; Delivery. Postpartum. Lactation; effect; Female; Fundamental and applied biological sciences. Psychology; Genetics of eukaryotes. Biological and molecular evolution; Gynecology. Andrology. Obstetrics; hemangioma; Hemangioma - epidemiology; Hemangioma - etiology; Humans; Incidence; Infant, Newborn; Male; Maternal Age; Medical sciences; Molecular and cellular biology; Netherlands - epidemiology; Odds Ratio; Parents; Pregnancy; prevalence; Skin Neoplasms - epidemiology; Skin Neoplasms - etiology; Surveys and Questionnaires; Netherlands; Human; hemangioma; Amniocentesis; Prevalence; Gynecology; Samplings; Neonatology; Cardiovascular disease; Epidemiology; Incidence; Vascular disease; Angioma; Prenatal diagnosis; Newborn; chorionic villus sampling; effect; Genetics; Sampling; Chorionic villi
• ISSN: 0197-3851; 1097-0223
• DOI: 10.1002/pd.2562

Objectives This study was designed to compare the effects of transcervical chorionic villus sampling (CVS) and amniocentesis on the prevalence of hemangiomas of infancy. Methods This is a cohort study of 250 consecutive assessable transabdominal amniocentesis procedures and 250 consecutive assessable transcervical CVS procedures performed between January and September 2002. Parents were asked to fill out a questionnaire regarding the presence of any type of skin lesions. Based on the responses to the questionnaire, children were invited to undergo a physical examination to confirm hemangiomas. Results Questionnaires were returned in 78% of the CVS group (195/250) and in 72% of the amniocentesis group (180/250). Based on the responses in the questionnaire, 78 children in the CVS group and 42 in the amniocentesis group underwent a physical examination. One or more hemangiomas were present in 53 of 195 (27.2%) children in the CVS group versus 17 of 180 (9.4%) children in the amniocentesis group (odds ratio 3.6, 95% CI: 2.0–6.5). There was no difference in congenital abnormalities between the two groups. Conclusion Transcervical CVS is associated with a significantly increased prevalence of hemangiomas compared with amniocentesis. The clinical features of these hemangiomas do not differ from natural hemangiomas and complications of these hemangiomas are very rare. Copyright © 2010 John Wiley & Sons, Ltd.