Increase of nitric oxide synthases and nitrotyrosine in inclusion-body myositis

• Published in: Neuroreport Vol. 8; no. 1; p. 153
• Main Authors: Yang, C C, Alvarez, R B, Engel, W K, Askanas, V
• Format: Journal Article
• Language: English
• Published: England 20.12.1996
• Subjects: Enzyme Induction - physiology; Fluorescent Antibody Technique, Indirect; Humans; Immunohistochemistry; Microscopy, Immunoelectron; Muscle Fibers, Skeletal - enzymology; Muscle Fibers, Skeletal - metabolism; Muscular Diseases - enzymology; Muscular Diseases - metabolism; Myositis, Inclusion Body - enzymology; Myositis, Inclusion Body - metabolism; Neurons - enzymology; Nitric Oxide Synthase - biosynthesis; Nitric Oxide Synthase - metabolism; Oxidative Stress - physiology; Tyrosine - analogs & derivatives; Tyrosine - metabolism

To investigate the possible role of nitric oxide (NO)-induced 'oxidative stress' in the pathogenesis of inclusion-body myositis (IBM), we immunostained muscle biopsies of 12 patients with IBM with isoform-specific antibodies against the neuronal and inducible forms of nitric oxide synthase...