CYP3A5 genotype has a dose-dependent effect on ABT-773 plasma levels - Katz, David A; Grimm, David R; Cassar, Steven C; Gentile, Maria C; Ye, Xin; Rieser, Matthew J; Gordon, Eric F; Polzin, Jill E; Gustavson, Linda E; Driscoll, Rita M; O'dea, Robert F; Williams, Laura A; et al. (Clinical pharmacology and therapeutics, 2004)
Keywords: Adolescent; Adult; Aged; Area Under Curve; Confidence Intervals; Cross-Over Studies; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System - genetics; Dose-Response Relationship, Drug; Double-Blind Method; Erythromycin - administration & dosage; Erythromycin - analogs & derivatives; Erythromycin - blood; Erythromycin - chemistry; Female; Genes, MDR - genetics; Genotype; Humans; Ketolides; Male; Middle Aged; Statistics, Nonparametric