Genetics in geographically structured populations: defining, estimating and interpreting FST

• Published in: Nature reviews. Genetics Vol. 10; no. 9; pp. 639 - 650
• Main Authors: Holsinger, Kent E., Weir, Bruce S.
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 01.09.2009; Nature Publishing Group
• Subjects: Agriculture; Animal Genetics and Genomics; Biological and medical sciences; Biomedical and Life Sciences; Biomedicine; Cancer Research; Estimates; Forensic sciences; Fundamental and applied biological sciences. Psychology; Gene Function; Genetic diversity; Genetics of eukaryotes. Biological and molecular evolution; Genomes; Human Genetics; Migration; Population; review-article; Statistics; United States > US; Genetics; Review

Key Points Wright's F -statistics, and especially F ST , provide important insights into the evolutionary processes that influence the structure of genetic variation within and among populations, and they are among the most widely used descriptive statistics in population and evolutionary genet...