The paradoxes of Mycobacterium tuberculosis molecular evolution and consequences for the inference of tuberculosis emergence date

• Published in: Tuberculosis (Edinburgh, Scotland) Vol. 143; p. 102378
• Main Authors: Zein-Eddine, R., Hak, F., Le Meur, A., Genestet, C., Dumitrescu, O., Guyeux, C., Senelle, G., Sola, C., Refrégier, G.
• Format: Journal Article
• Language: English
• Published: Scotland Elsevier Ltd 01.12.2023; Elsevier
• Subjects: Bacteriology; Biodiversity; Evolution, Molecular; Human health and pathology; Humans; Infectious diseases; Life Sciences; Microbiology and Parasitology; Mutation rate; Mycobacterium tuberculosis - genetics; Pathogen; Populations and Evolution; Positive selection; Pulmonology and respiratory tract; Purifying selection; Substitution rate; Tuberculosis - diagnosis; Tuberculosis - genetics; Tuberculosis - microbiology; Mutation rate; Substitution rate; Pathogen; Positive selection; Purifying selection

The date of Mycobacterium tuberculosis complex emergence has been the subject of long debates. New studies joining archaeological efforts with sequencing methods raise high hopes for solving whether this emergence is closer to 70,000 or to 6000 years before present. Inferring the date of emergence o...