Suppressing long noncoding RNA OGRU ameliorates diabetic retinopathy by inhibition of oxidative stress and inflammation via miR-320/USP14 axis

• Published in: Free radical biology & medicine Vol. 169; pp. 361 - 381
• Main Authors: Fu, Shuhua, Zheng, Yunyao, Sun, Yawen, Lai, Meichen, Qiu, Jingjing, Gui, Fu, Zeng, Qinqin, Liu, Fei
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.06.2021
• Subjects: Animals; Diabetes Mellitus; Diabetic retinopathy (DR); Diabetic Retinopathy - genetics; Humans; Inflammation - genetics; Inflammation and oxidative stress; LncRNA-OGRU; MicroRNAs - genetics; MicroRNAs - metabolism; miR-320/USP14; Oxidative Stress - genetics; Rats; RNA, Long Noncoding - genetics; RNA, Long Noncoding - metabolism; Ubiquitin Thiolesterase - genetics; Ubiquitination; Vascular Endothelial Growth Factor A - metabolism; Inflammation and oxidative stress; miR-320/USP14; Ubiquitination; Diabetic retinopathy (DR); LncRNA-OGRU

Long noncoding RNAs (lncRNAs) are important regulators in various diseases including diabetic retinopathy (DR). In this study, DR patients exhibited significantly increased expression of serum LncRNA-OGRU compared with normal individuals. Streptozotocin (STZ)-challenged rats with DR also had higher...