Identification of leukemia-specific fusion gene transcripts with a novel oligonucleotide array

• Published in: Molecular diagnosis & therapy Vol. 11; no. 1; pp. 21 - 28
• Main Authors: Chun, Sung-Min, Kim, Yoo-Li, Choi, Hee Baeg, Oh, Yong-Taek, Kim, Yoo-Jin, Lee, Seok, Kim, Tai-Gyu, Yang, Eun Gyeong, Park, Yong-Keun, Kim, Dong-Wook, Han, Byoung-Don
• Format: Journal Article
• Language: English
• Published: New Zealand Wolters Kluwer Health, Inc 2007
• Subjects: Cell Line, Tumor; Chromosomes, Human, Pair 15; Chromosomes, Human, Pair 21; DNA, Complementary; DNA, Neoplasm - genetics; DNA, Single-Stranded - genetics; Gene Fusion; Humans; K562 Cells; Leukemia - genetics; Oligonucleotide Array Sequence Analysis; RNA, Neoplasm - genetics; Transcription, Genetic; Translocation, Genetic

Identification of specific chromosomal translocations is essential for the diagnosis and prognosis of leukemia. In this study, we employ DNA microarray technology to detect chromosomal aberrations in patients with chronic myeloid leukemia (CML) and acute myeloid leukemia (AML), as well as in leukemi...