Increased plasma levels of the lipoperoxyl radical-derived vitamin E metabolite α-tocopheryl quinone are an early indicator of lipotoxicity in fatty liver subjects

• Published in: Free radical biology & medicine Vol. 131; pp. 115 - 125
• Main Authors: Torquato, Pierangelo, Bartolini, Desirée, Giusepponi, Danilo, Piroddi, Marta, Sebastiani, Bartolomeo, Saluti, Giorgio, Galarini, Roberta, Galli, Francesco
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.02.2019
• Subjects: 4-HNE; Adult; Alanine Transaminase - blood; Aldehydes - blood; alpha-Tocopherol - administration & dosage; alpha-Tocopherol - blood; Bilirubin - blood; Cholesterol, LDL - blood; Cross-Sectional Studies; Eicosanoids; Fatty Acids, Unsaturated - blood; Fatty liver; Female; Free Radical Scavengers - administration & dosage; Free Radical Scavengers - blood; Gas Chromatography-Mass Spectrometry; Hepatocytes - metabolism; Hepatocytes - pathology; Humans; Lipid Peroxidation; Liver - metabolism; Liver - pathology; Male; Middle Aged; NAFLD; NASH; Non-alcoholic Fatty Liver Disease - blood; Non-alcoholic Fatty Liver Disease - diagnosis; Non-alcoholic Fatty Liver Disease - pathology; Pilot Projects; Polyunsaturated fatty acids; Triglycerides - blood; Vitamin E; Vitamin E - analogs & derivatives; Vitamin E - blood; α-tocopherol; α-tocopheryl quinone; NAFLD; Fatty liver; 4-HNE; Vitamin E; Polyunsaturated fatty acids; Eicosanoids; NASH; α-tocopherol; α-tocopheryl quinone

Lipid peroxidation is one of the earliest pathogenic events of non-alcoholic fatty liver disease (NAFLD). In this context, an increased oxidation of the lipoperoxyl radical scavenger α-tocopherol (α-TOH) should occur already in the subclinical phases of the disease to compensate for the increase oxi...