Spleen tyrosine kinase regulates keratinocyte inflammasome activation and skin inflammation induced by UVB irradiation

• Published in: Free radical biology & medicine Vol. 180; pp. 121 - 133
• Main Authors: Lu, Po-Hsuan, Wang, Jen-Yu, Chiu, Ling-Ya, Huang, Yi-Ting, Hung, Chi-Feng, Wu, Nan-Lin
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 20.02.2022
• Subjects: IL-1β; IL-8; Inflammasome; Keratinocyte; ROS; Syk; TNF-α; UVB; UVB; Syk; TNF-α; ROS; Keratinocyte; Inflammasome; IL-1β; IL-8

UVB can induce inflammatory responses contributing to diverse skin damage. UVB-triggered inflammasome activation of human keratinocytes underlies UVB-induced skin sunburn reaction. Pleiotropic functions of spleen tyrosine kinase (Syk) have rendered it as a potential therapeutic target. In immunocyte...