Cognitive Translation Using the Rodent Touchscreen Testing Approach
The development of novel therapeutic avenues for the treatment of cognitive deficits in psychiatric and neurodegenerative disease is of high importance, yet progress in this field has been slow. One reason for this lack of success may lie in discrepancies between how cognitive functions are assessed...
Saved in:
Published in | Current topics in behavioral neurosciences Vol. 28; p. 423 |
---|---|
Main Authors | , , , |
Format | Journal Article |
Language | English |
Published |
Germany
2016
|
Subjects | |
Online Access | Get more information |
Cover
Loading…
Abstract | The development of novel therapeutic avenues for the treatment of cognitive deficits in psychiatric and neurodegenerative disease is of high importance, yet progress in this field has been slow. One reason for this lack of success may lie in discrepancies between how cognitive functions are assessed in experimental animals and humans. In an attempt to bridge this translational gap, the rodent touchscreen testing platform is suggested as a translational tool. Specific examples of successful cross-species translation are discussed focusing on paired associate learning (PAL), the 5-choice serial reaction time task (5-CSRTT), the rodent continuous performance task (rCPT) and reversal learning. With ongoing research assessing the neurocognitive validity of tasks, the touchscreen approach is likely to become increasingly prevalent in translational cognitive research. |
---|---|
AbstractList | The development of novel therapeutic avenues for the treatment of cognitive deficits in psychiatric and neurodegenerative disease is of high importance, yet progress in this field has been slow. One reason for this lack of success may lie in discrepancies between how cognitive functions are assessed in experimental animals and humans. In an attempt to bridge this translational gap, the rodent touchscreen testing platform is suggested as a translational tool. Specific examples of successful cross-species translation are discussed focusing on paired associate learning (PAL), the 5-choice serial reaction time task (5-CSRTT), the rodent continuous performance task (rCPT) and reversal learning. With ongoing research assessing the neurocognitive validity of tasks, the touchscreen approach is likely to become increasingly prevalent in translational cognitive research. |
Author | Nilsson, S R O Saksida, L M Hvoslef-Eide, M Bussey, T J |
Author_xml | – sequence: 1 givenname: M surname: Hvoslef-Eide fullname: Hvoslef-Eide, M email: mh473@cam.ac.uk organization: Department of Psychology, University of Cambridge, Cambridge, CB2 3EB, UK. mh473@cam.ac.uk – sequence: 2 givenname: S R O surname: Nilsson fullname: Nilsson, S R O organization: Department of Psychology, University of Cambridge, Cambridge, CB2 3EB, UK – sequence: 3 givenname: L M surname: Saksida fullname: Saksida, L M organization: Department of Psychology, University of Cambridge, Cambridge, CB2 3EB, UK – sequence: 4 givenname: T J surname: Bussey fullname: Bussey, T J organization: Department of Psychology, University of Cambridge, Cambridge, CB2 3EB, UK |
BackLink | https://www.ncbi.nlm.nih.gov/pubmed/27305921$$D View this record in MEDLINE/PubMed |
BookMark | eNo1T19LwzAczMPEzblXHyVfoJq_TfI4ijphIEj3XNLk17WyJaXJBL-9FfUe7jgOjrsbtAgxAEJ3lDxQQtSj0lI0jFDZyNku0Irqsiw4V2SJNil9kBmypNrQa7RkihNpGF2hqorHMOThE3A92ZBONg8x4EMawhHnHvB79BAyruPF9clNAAHXkPJPvB3HKVrX36Krzp4SbP50jQ7PT3W1K_ZvL6_Vdl84rnme2UhZeg7GcvDMecaodZI7pZU3UreSSaMEdC0YQR3pdCk6Pa_03CsrNFuj-9_e8dKewTfjNJzt9NX8v2HfwOBMgw |
CitedBy_id | crossref_primary_10_1111_gbb_12652 crossref_primary_10_1111_gbb_12663 crossref_primary_10_3389_fnbeh_2019_00048 crossref_primary_10_1002_jnr_25160 crossref_primary_10_1097_FBP_0000000000000356 crossref_primary_10_1016_j_avb_2020_101477 crossref_primary_10_3389_fnbeh_2021_722780 crossref_primary_10_1016_j_neubiorev_2018_09_025 crossref_primary_10_1038_s41684_021_00791_2 crossref_primary_10_1016_j_nlm_2017_01_006 crossref_primary_10_1111_gbb_12705 crossref_primary_10_1016_j_bbr_2023_114659 crossref_primary_10_1038_s41386_018_0208_4 crossref_primary_10_1016_j_lssr_2021_03_008 crossref_primary_10_1038_s41598_018_34966_8 crossref_primary_10_31887_DCNS_2019_21_3_mrossner crossref_primary_10_1016_j_expneurol_2022_114104 crossref_primary_10_1016_j_jneumeth_2022_109779 crossref_primary_10_3389_fnbeh_2018_00226 crossref_primary_10_1016_j_cobeha_2017_12_008 crossref_primary_10_1038_s41598_020_59419_z crossref_primary_10_3389_fnmol_2018_00041 |
ContentType | Journal Article |
DBID | CGR CUY CVF ECM EIF NPM |
DOI | 10.1007/7854_2015_5007 |
DatabaseName | Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed |
DatabaseTitle | MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) |
DatabaseTitleList | MEDLINE |
Database_xml | – sequence: 1 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: EIF name: MEDLINE url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search sourceTypes: Index Database |
DeliveryMethod | no_fulltext_linktorsrc |
ExternalDocumentID | 27305921 |
Genre | Journal Article Review |
GroupedDBID | --- 53G ACGFS ALMA_UNASSIGNED_HOLDINGS CGR CUY CVF ECM EIF F5P NPM RSU |
ID | FETCH-LOGICAL-c383t-c39556d3e9a3ed2cd221ac53c787d958b525974efbe941c0f864f8921d3d7a482 |
ISSN | 1866-3370 |
IngestDate | Thu May 23 23:23:19 EDT 2024 |
IsPeerReviewed | true |
IsScholarly | true |
Keywords | Human Touchscreen Translation Cognition Mouse Rat |
Language | English |
LinkModel | OpenURL |
MergedId | FETCHMERGED-LOGICAL-c383t-c39556d3e9a3ed2cd221ac53c787d958b525974efbe941c0f864f8921d3d7a482 |
PMID | 27305921 |
ParticipantIDs | pubmed_primary_27305921 |
PublicationCentury | 2000 |
PublicationDate | 2016 |
PublicationDateYYYYMMDD | 2016-01-01 |
PublicationDate_xml | – year: 2016 text: 2016 |
PublicationDecade | 2010 |
PublicationPlace | Germany |
PublicationPlace_xml | – name: Germany |
PublicationTitle | Current topics in behavioral neurosciences |
PublicationTitleAlternate | Curr Top Behav Neurosci |
PublicationYear | 2016 |
SSID | ssj0000561891 |
Score | 2.093205 |
SecondaryResourceType | review_article |
Snippet | The development of novel therapeutic avenues for the treatment of cognitive deficits in psychiatric and neurodegenerative disease is of high importance, yet... |
SourceID | pubmed |
SourceType | Index Database |
StartPage | 423 |
SubjectTerms | Animals Association Learning - physiology Cognition - physiology Humans Mice Psychomotor Performance - physiology Rats Reaction Time - physiology Reversal Learning - physiology |
Title | Cognitive Translation Using the Rodent Touchscreen Testing Approach |
URI | https://www.ncbi.nlm.nih.gov/pubmed/27305921 |
Volume | 28 |
hasFullText | |
inHoldings | 1 |
isFullTextHit | |
isPrint | |
link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1NT9wwELWgXHpBRQVaWpAP3KLQTWzHzrFdUa2qskgoSNyi-Eta0W5W2iwHfn3HsfMBBdRysVZxZK0zb2fHk3lvEDpllaDKmiq2OpExpRWLJdc6TnRGJqlODJeOKHwxz2bX9McNuxlS2S27pJFn6v5JXslrrArXwK6OJfsflu0XhQvwGewLI1gYxn-y8bSv_Wn_cnxZW-SrAFxAeVU7Gm5U1BtHP3EVNlHhVDVcJiRoiY-D006rqalXTrt5sRyT-EfCl0PZ4eyuXv8yNj5faPMgtTpfuL373Gp0FV32iZzqFh5TG7D-HO7-tlmH91dFeE0V8hDJOA_hXafIspgQ3wak862B-O2dI_XM4r-ctq_T4ILREhZmJZv4RrgjC65-tyaEWAvCQU-pfnn2kYh2N7WNtrlwHT7mIanjJeCzxPdW7PfQyXtO-JeH38uJR4e1Hh1E2oCkeId2w0kCf_Ww2ENbZvkeTXtI4BEkcAsJDJDAHhJ4BAkcIIE7SOyj6-_nxXQWhz4ZsSKCNDDmjGWamLwiRqdKp2lSKUYUOGOdMyFZ6o6NxkqT00RNrMioFbADTTSvqEgP0JtlvTQfELbgn129cUalpSkclZkySsIijPOcs-ojOvR7LldeDKXsnsbRszOf0NsBL5_RjoVfnzmGUK6RJ60h_gDxv0ZC |
link.rule.ids | 780 |
linkProvider | National Library of Medicine |
openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Cognitive+Translation+Using+the+Rodent+Touchscreen+Testing+Approach&rft.jtitle=Current+topics+in+behavioral+neurosciences&rft.au=Hvoslef-Eide%2C+M&rft.au=Nilsson%2C+S+R+O&rft.au=Saksida%2C+L+M&rft.au=Bussey%2C+T+J&rft.date=2016-01-01&rft.issn=1866-3370&rft.volume=28&rft.spage=423&rft_id=info:doi/10.1007%2F7854_2015_5007&rft_id=info%3Apmid%2F27305921&rft_id=info%3Apmid%2F27305921&rft.externalDocID=27305921 |
thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=1866-3370&client=summon |
thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=1866-3370&client=summon |
thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=1866-3370&client=summon |