Roles of Silk Fibroin on Characteristics of Hyaluronic Acid/Silk Fibroin Hydrogels for Tissue Engineering of Nucleus Pulposus

• Published in: Materials Vol. 13; no. 12; p. 2750
• Main Authors: Chung, Tze-Wen, Chen, Weng-Pin, Tai, Pei-Wen, Lo, Hsin-Yu, Wu, Ting-Ya
• Format: Journal Article
• Language: English
• Published: Basel MDPI AG 17.06.2020; MDPI
• Subjects: Amino acids; Biomedical materials; Bone marrow; Butanediol; Cell growth; Collagen; Crosslinking; Differentiation; Glycosaminoglycans; Growth factors; Hyaluronic acid; Hydrogels; Hydrogen peroxide; Mechanical properties; Modules; Molecular weight; Peroxidase; Polymers; Polyvinyl alcohol; Proteins; Scaffolds; Silk fibroin; Stem cells; Tissue engineering; Tyrosine; Viscoelasticity; St Louis Missouri; United States > US

Silk fibroin (SF) and hyaluronic acid (HA) were crosslinked by horseradish peroxidase (HRP)/H2O2, and 1,4-Butanediol di-glycidyl ether (BDDE), respectively, to produce HA/SF-IPN (interpenetration network) (HS-IPN) hydrogels. HS-IPN hydrogels consisted of a SF strain with a high content of tyrosine (...