Involvement of the endocannabinoid system in periodontal healing

• Published in: Biochemical and biophysical research communications Vol. 394; no. 4; pp. 928 - 933
• Main Authors: Kozono, Sayaka, Matsuyama, Takashi, Biwasa, Kamal Krishna, Kawahara, Ko-ichi, Nakajima, Yumiko, Yoshimoto, Takehiko, Yonamine, Yutaka, Kadomatsu, Hideshi, Tancharoen, Salunya, Hashiguchi, Teruto, Noguchi, Kazuyuki, Maruyama, Ikuro
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 16.04.2010
• Subjects: 60 APPLIED LIFE SCIENCES; Animals; Arachidonic Acids - metabolism; Arachidonic Acids - pharmacology; Cannabinoid Receptor Modulators - metabolism; Cannabinoid Receptor Modulators - pharmacology; Cannabinoid receptors; Cell Proliferation; Endocannabinoids; FIBROBLASTS; Fibroblasts - drug effects; Fibroblasts - metabolism; Fibroblasts - physiology; Gingival Crevicular Fluid - metabolism; Gingival fibroblasts; Glycerides - metabolism; Glycerides - pharmacology; GRANULATION; GTP-ASES; HEALING; Humans; IN VITRO; Indoles - pharmacology; LIPIDS; MACROPHAGES; Mitogen-activated protein kinases; ORGANS; p38 Mitogen-Activated Protein Kinases - metabolism; Periodontium - injuries; Periodontium - metabolism; Phosphatidylinositol 3-Kinases - metabolism; PHOSPHORYLATION; PHOSPHOTRANSFERASES; Piperidines - pharmacology; Polyunsaturated Alkamides - metabolism; Polyunsaturated Alkamides - pharmacology; Proliferation; Pyrazoles - pharmacology; RATS; Receptor, Cannabinoid, CB1 - antagonists & inhibitors; Receptor, Cannabinoid, CB1 - metabolism; Receptor, Cannabinoid, CB2 - antagonists & inhibitors; Receptor, Cannabinoid, CB2 - metabolism; RECEPTORS; Wound Healing; WOUNDS; Wound healing; Proliferation; Endocannabinoids; Gingival fibroblasts; Cannabinoid receptors; Mitogen-activated protein kinases

Endocannabinoids including anandamide (AEA) and 2-arachidonoylglycerol (2-AG) are important lipid mediators for immunosuppressive effects and for appropriate homeostasis via their G-protein-coupled cannabinoid (CB) receptors in mammalian organs and tissues, and may be involved in wound healing in so...