Risk of upper gastrointestinal bleeding and perforation associated with Individual non-steroidal anti-inflammatory drugs

• Published in: The Lancet (British edition) Vol. 343; no. 8900; pp. 769 - 772
• Main Authors: García Rodríguez, La, Jick, H.
• Format: Journal Article
• Language: English
• Published: London Elsevier Ltd 26.03.1994; Lancet; Elsevier Limited
• Subjects: Adult; Aged; Anti-inflammatory agents; Anti-Inflammatory Agents, Non-Steroidal - administration & dosage; Anti-Inflammatory Agents, Non-Steroidal - adverse effects; Anticoagulants; Biological and medical sciences; Bleeding; Case studies; Case-Control Studies; Corticoids; Corticosteroids; Data processing; Diclofenac; Drug dosages; Drug toxicity and drugs side effects treatment; Drugs; Female; Gastrointestinal Hemorrhage - chemically induced; Gastrointestinal Hemorrhage - epidemiology; Health risk assessment; Humans; Ibuprofen; Indomethacin; Inflammation; Intestinal Perforation - chemically induced; Intestinal Perforation - epidemiology; Ketoprofen; Male; Medical research; Medical sciences; Middle Aged; Naproxen; Nonsteroidal anti-inflammatory drugs; Perforation; Pharmacology. Drug treatments; Piroxicam; Population studies; Population Surveillance; Retrospective Studies; Risk analysis; Risk Factors; Smoking; Toxicity: digestive system; United Kingdom; Non steroidal antiinflammatory agent; Human; Stomach; Perforation; Toxicity; Gut; Digestive diseases; Intestinal disease; Gastrointestinal; Hemorrhage; Gastric disease

Exposure to non-steroidal anti-inflammatory drugs (NSAIDs) is known to increase substantially the risk of upper gastrointestinal bleeding and perforation (UGIB). We have carried out a population-based retrospective case-control study to assess the variation in risk associated with various individual...