Multivariate statistical analysis of metabolomics profiles in tissues of polar bears (Ursus maritimus) from the Southern and Western Hudson Bay subpopulations

• Published in: Polar biology Vol. 41; no. 3; pp. 433 - 449
• Main Authors: Morris, A. D., Letcher, R. J., Dyck, M., Chandramouli, B., Fisk, A. T., Cosgrove, J.
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Springer Berlin Heidelberg 01.03.2018; Springer; Springer Nature B.V
• Subjects: Amines; Amino acids; Analysis; Anthropogenic factors; Aquatic mammals; Arginine; Biogenic amines; Biological effects; Biomedical and Life Sciences; Ecology; Fatty acids; Glutamine; Hexoses; Human influences; Isotope ratios; Leucine; Life Sciences; Liquid chromatography; Liver; Males; Marine mammals; Mass spectrometry; Mass spectroscopy; Metabolites; Metabolomics; Microbiology; Multivariate analysis; Multivariate statistical analysis; Muscles; Oceanography; Original Paper; Physiological aspects; Plant Sciences; Polar bear; Polar bears; Predators; Profiles; Ratios; Sphingomyelin; Stable isotopes; Statistical analysis; Statistical methods; Subpopulations; Tissue; Ursus maritimus; Vasoactive intestinal peptide; Zoology; Hudson Bay; Partial least squares discriminant analysis (PLS-DA); Metabolomics; ); Polar bears; Multivariate analysis; Hudson Bay

Polar bears ( Ursus maritimus ) are apex predators of the Arctic, which exposes them to an array of natural and anthropogenic stress factors. Metabolomics analysis profiles endogenous metabolites that reflect the response of biological systems to stimuli, and the effects of multiple stressors can be...