Activation of PINK1-mediated mitophagy protects bovine mammary epithelial cells against lipopolysaccharide-induced mitochondrial and inflammatory damage in vitro

• Published in: Free radical biology & medicine Vol. 194; pp. 172 - 183
• Main Authors: Chang, Renxu, Tang, Yan, Jia, Hongdou, Dong, Zhihao, Gao, Shuang, Song, Qian, Dong, Hao, Xu, Qiushi, Jiang, Qianming, Loor, Juan J., Sun, Xudong, Xu, Chuang
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.01.2023
• Subjects: Animals; Autophagy; Bovine mammary epithelial cells; Cattle; Epithelial Cells - metabolism; Female; Inflammasomes - metabolism; Lipopolysaccharides - pharmacology; Mitochondria - metabolism; Mitochondrial damage; Mitophagy; NLR Family, Pyrin Domain-Containing 3 Protein - metabolism; NLRP3; PINK1; Protein Kinases - genetics; Protein Kinases - metabolism; Reactive Oxygen Species - metabolism; NLRP3; PINK1; Bovine mammary epithelial cells; Mitophagy; Mitochondrial damage

Increased metabolic stress during early lactation results in damage of mitochondria and inflammatory responses in bovine mammary epithelial cells, both of which could be aggravated by inhibition of mitophagy. PTEN-induced putative kinase 1 (PINK1)-mediated mitophagy is essential in the removal of da...