The Role of Andrographolide on Skin Inflammations and Modulation of Skin Barrier Functions in Human Keratinocyte

• Published in: Biotechnology and bioprocess engineering Vol. 26; no. 5; pp. 804 - 813
• Main Authors: Bayazid, Al Borhan, Jang, Young Ah
• Format: Journal Article
• Language: English
• Published: Seoul The Korean Society for Biotechnology and Bioengineering 01.10.2021; Springer Nature B.V; 한국생물공학회
• Subjects: Allergies; Andrographis paniculata; andrographolide; Antioxidants; Atopic dermatitis; Bioavailability; Biocompatibility; bioprocessing; Biotechnology; c-Fos protein; Cell viability; Chemical compounds; Chemistry; Chemistry and Materials Science; Confocal microscopy; Cyclooxygenase-2; Cytokines; Cytotoxicity; Dermatitis; Enzyme-linked immunosorbent assay; Filaggrin; Herbal medicine; humans; inducible nitric oxide synthase; Industrial and Production Engineering; inflammation; Interleukin 6; Keratinocytes; Lipopolysaccharides; Medicinal plants; NF-κB protein; Nitric oxide; Nitric-oxide synthase; Pharmacology; Prostaglandin E2; prostaglandin synthase; prostaglandins; Psoriasis; Research Paper; Skin diseases; therapeutics; Toxicity; transcription factor NF-kappa B; Tumor necrosis factor-TNF; Tumor necrosis factor-α; Western blotting; γ-Interferon; 생물공학; skin inflammations; bioactive nutrient; keratinocyte; skin permeability; andrographolide

Andrographolide (AG) is a bioactive natural occurring compound found in a medicinal plant called Andrographis paniculata . AG is highly bioavailable and well-known for anti-cancer, antioxidant, anti-inflammatory, and many other bio-functional activities. Hence, its anti-inflammatory effects in kerat...