CAPE and its synthetic derivative VP961 restore BACH1/NRF2 axis in Down Syndrome

• Published in: Free radical biology & medicine Vol. 183; pp. 1 - 13
• Main Authors: Pagnotta, Sara, Tramutola, Antonella, Barone, Eugenio, Di Domenico, Fabio, Pittalà, Valeria, Salerno, Loredana, Folgiero, Valentina, Caforio, Matteo, Locatelli, Franco, Petrini, Stefania, Butterfield, D. Allan, Perluigi, Marzia
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.04.2022
• Subjects: Animals; BACH1; Basic-Leucine Zipper Transcription Factors - genetics; Basic-Leucine Zipper Transcription Factors - metabolism; Caffeic Acids; Down Syndrome; Humans; Kelch-Like ECH-Associated Protein 1 - genetics; Kelch-Like ECH-Associated Protein 1 - metabolism; Mice; NF-E2-Related Factor 2 - genetics; NF-E2-Related Factor 2 - metabolism; NRF2; Oxidative Stress; Phenylethyl Alcohol - analogs & derivatives; Oxidative stress; Down syndrome; NRF2; BACH1

The cells possess several mechanisms to counteract the over-production of reactive oxygen species (ROS) and reactive nitrogen species (RNS), including enzymes such as superoxide dismutase, catalase and glutathione peroxidase. Moreover, an important sensor involved in the anti-oxidant response is KEA...