Investigation of N-Acetyllactosamine and N,N-Diacetyllactosamine Residues of Seminal Plasma Prolactin-Induced Protein as Ligands Recognized by Galectin-3

• Published in: International journal of molecular sciences Vol. 25; no. 24; p. 13432
• Main Authors: Kałuża, Anna, Trzęsicka, Katarzyna, Drzyzga, Damian, Ferens-Sieczkowska, Mirosława
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 15.12.2024
• Subjects: Adult; Amino Sugars - metabolism; Analysis; Antigenic determinants; Blood Proteins; Carbohydrates; Galactose; Galectin 3 - metabolism; Galectins; Glycodelin; Glycoproteins; Glycoproteins - metabolism; Humans; Immunomodulators; Infertility; Inflammation; Investigations; Lectins; Ligands; Male; Membrane Transport Proteins; Plant Lectins - chemistry; Plant Lectins - metabolism; Plasma; Polysaccharides; Polysaccharides - chemistry; Polysaccharides - metabolism; Preferences; Prolactin; Protein Binding; Proteins; Semen - chemistry; Semen - metabolism; Sperm; United Kingdom; seminal plasma; immunomodulatory epitopes; N-acetyllactosamine; prolactin-induced protein; carbohydrate protein interaction; N,N-diacetyllactosamine; galectin-3

Prolactin induced-protein (PIP) has been found to be rich in immunomodulatory epitopes, including N-acetyllactosamine (LacNAc) and N,N-diacetyllactosamine (LacdiNAc) residues, which may constitute ligands for galecin-3 (Gal-3). In the current study, we aimed to investigate the reactivity of galactos...