Stimuli-responsive nanocarriers constructed from pillar[]arene-based supra-amphiphiles
Supra-amphiphiles assembled by macrocycle-based host-guest interactions have received considerable attention in recent years due to their dynamic properties and wide applications. Pillar[ n ]arenes are a unique family of macrocycles which exhibit outstanding host-guest behavior. Developing water-sol...
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| Published in | Materials chemistry frontiers Vol. 3; no. 1; pp. 1973 - 1993 |
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| Main Authors | , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
London
Royal Society of Chemistry
01.10.2019
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| Subjects | |
| Online Access | Get full text |
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| Summary: | Supra-amphiphiles assembled by macrocycle-based host-guest interactions have received considerable attention in recent years due to their dynamic properties and wide applications. Pillar[
n
]arenes are a unique family of macrocycles which exhibit outstanding host-guest behavior. Developing water-soluble pillar[
n
]arene (WP[
n
]) based supra-amphiphiles is an effective way to introduce this special macrocycle into functional nanomaterials through controlled self-assembly. Specifically, WP[
n
]-based supra-amphiphiles can further form different nanomaterials, such as micelles, vesicles, and other types of nanoparticles (NPs), which may become good candidates for nanocarriers of payloads. Herein, we highlight recent significant achievements in functional nanocarriers fabricated from supra-amphiphiles based on WP[
n
]s. By showing a series of examples, the preparation strategies, characterization, and stimuli-responsive behaviors of these nano-sized assemblies based on WP[
n
] derivatives are described. Furthermore, some important applications of WP[
n
]-based nanocarriers, such as drug/gene/protein delivery, photodynamic/photothermal therapy, and optical materials, are discussed in detail. Finally, future challenges and research directions in this rapidly evolving field are outlined.
Recent progress of functional nanocarriers fabricated by pillar[
n
]arene-based supra-amphiphiles is reviewed. |
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| Bibliography: | Leyong Wang holds a PhD in Chemistry from Nanjing University in 2000. After research stays at the Institute of Chemistry (CAS), the University of Burgundy, and Mainz University from 2000 to 2004, he joined the Erlangen-Nürnberg University as an AvH Fellow working with Professor John A. Gladysz. Since 2006, he has been specially appointed as the professor of organic and material chemistry at NJU. He is also a joint professor of Changzhou University since 2017. His current research interests are focused on supramolecular systems ranging from topological molecules to dynamic materials. Ruibing Wang received his B.Sc. degree in Chemistry from Jilin University in 2002 and PhD degree in Organic Chemistry from Queen's University (Canada) in 2007. After a brief stay as a Postdoctoral Fellow at Queen's University, he moved to the National Research Council of Canada as a Research Associate for about two years. Between 2009 and 2014, he worked as a Senior Scientist at BTG plc, Canada. He joined the University of Macau as an Assistant Professor in Pharmaceutical Sciences in late 2014, and was recently promoted to Associate Professor. His current research interests are focused on supramolecular medicine and pharmaceutics. Tangxin Xiao is a Lecturer at the School of Petrochemical Engineering, Changzhou University. He studied chemistry at Nanjing University where he received his PhD degree under the supervision of Prof. Leyong Wang in 2014. He had been to the University of Cambridge as a visiting PhD student supervised by Prof. Oren Scherman in 2013. After postdoctoral research on fine chemicals at the Zhejiang University-NHU Company United R&D Center, he joined Changzhou University in 2017. His current research interests concern supramolecular self-assembly and smart materials. Chen Lin was born in Jiangsu in China in 1979. He obtained his B.Sc. from Nankai University in China in 2001 and PhD from SUNY at Stony Brook in USA in 2005. Afterwards, he joined Nanjing University as an Assistant Professor in 2006. Currently he is an Associate professor at Nanjing University. His research interests are in the areas of supramolecular chemistry, molecular recognition, and smart materials. Lijie Qi was born in Henan province, China. She obtained her B.Sc. degree from Shangqiu Normal University in 2018. She is currently pursuing her Master's degree under the supervision of Dr Tangxin Xiao and Prof. Leyong Wang at Changzhou University. Her research interests are focused on quadruple hydrogen bonding supramolecular polymers. Weiwei Zhong was born in Jiangsu, China. She received her B.Sc. degree in Changzhou University in 2017. She is currently pursuing her M.Sc. degree under the supervision of Prof. Leyong Wang and Dr Tangxin Xiao at Changzhou University. Her research interests are focused on quadruple hydrogen bonding supramolecular polymers. ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 |
| ISSN: | 2052-1537 2052-1537 |
| DOI: | 10.1039/c9qm00428a |