Iso-seco-tanapartholide activates Nrf2 signaling pathway through Keap1 modification and oligomerization to exert anti-inflammatory effects - Zhu, Dongrong; Xia, Yuanzheng; Li, Shang; Kong, Min; Chen, Chen; Xue, Guimin; Kong, Lingyi; Luo, Jianguang (Free radical biology & medicine, 2022)
Keywords: Anti-inflammatory; Anti-Inflammatory Agents - pharmacology; Iso-seco-tanapartholide; Keap1 dimer; Kelch-Like ECH-Associated Protein 1 - genetics; Kelch-Like ECH-Associated Protein 1 - metabolism; NF-E2-Related Factor 2 - genetics; NF-E2-Related Factor 2 - metabolism; NF-kappa B - genetics; NF-kappa B - metabolism; Nrf2; Oligomerization; Signal Transduction; NO; Oligomerization; DTT; H&E; βME; DARTS; IST; LPS; CETSA; NAC; RNA-seq; ARE; Nrf2; DEX; Keap1 dimer; ROS; Iso-seco-tanapartholide; Keap1; Anti-inflammatory; GSH; ELISA