Reduced IκB-α Protein Levels in Peripheral Blood Cells of Patients with Multiple Sclerosis—A Possible Cause of Constitutive NF-κB Activation

• Published in: Journal of clinical medicine Vol. 9; no. 8; p. 2534
• Main Authors: Yan, Jun, McCombe, Pamela A., Pender, Michael P., Greer, Judith M.
• Format: Journal Article
• Language: English
• Published: Basel MDPI AG 06.08.2020; MDPI
• Subjects: Antibodies; Clinical medicine; Cloning; Inflammation; Kinases; Multiple sclerosis; Phosphorylation; Proteins; Tumor necrosis factor-TNF; Australia; United States > US

NF-κB signaling pathways are dysregulated in both the central nervous system (CNS) and peripheral blood cells in multiple sclerosis (MS), but the cause of this is unknown. We have recently reported that peripheral blood mononuclear cells (PBMC) of patients with MS have increased constitutive activat...