Expression of apoptosis-related proteins in rat with induced colitis

• Published in: International journal of colorectal disease Vol. 19; no. 5; pp. 451 - 460
• Main Authors: D’Argenio, Giuseppe, Farrace, Maria Grazia, Cosenza, Vittorio, De Ritis, Francesca, Della Valle, Nicola, Manguso, Francesco, Piacentini, Mauro
• Format: Journal Article
• Language: English
• Published: Heidelberg Springer 01.09.2004; Berlin Springer Nature B.V
• Subjects: Animals; Antigens, Surface; Apoptosis; Biological and medical sciences; Biomarkers - analysis; Biopsy; Colitis - genetics; Colitis - physiopathology; Colitis - veterinary; Disease Models, Animal; Fas Ligand Protein; fas Receptor - analysis; fas Receptor - biosynthesis; Gastroenterology. Liver. Pancreas. Abdomen; In Situ Nick-End Labeling; Ligands; Male; Medical sciences; Membrane Glycoproteins; Rats; Rats, Wistar; Transglutaminases - analysis; Transglutaminases - biosynthesis; Transglutaminases - pharmacology; Trinitrobenzenesulfonic Acid - administration & dosage; Trinitrobenzenesulfonic Acid - adverse effects; Tumor Suppressor Protein p53 - analysis; Tumor Suppressor Protein p53 - biosynthesis; Apoptosis markers; Rat; Rodentia; Rats; Marker; Protein; Apoptosis-related proteins; Vertebrata; Mammalia; Animal; Gastroenterology; Digestive diseases; Intestinal disease; Colitis; Induced colitis; Apoptosis

Inflammatory bowel diseases (IBD) evoke a damage-repair process accompanied by the activation of apoptotic genes. Data on transglutaminase (TG) expression in apoptotic cells in inflamed colonic epithelium has not been reported, although TG cross-links proteins within typical apoptotic bodies in vari...