Heme-nitrosylated hemoglobin and oxidative stress in women consuming combined contraceptives. Clinical application of the EPR spectroscopy

• Published in: Free radical biology & medicine Vol. 108; pp. 524 - 532
• Main Authors: Lobysheva, Irina I., van Eeckhoudt, Sandrine, Dei Zotti, Flavia, Rifahi, Ahmad, Pothen, Lucie, Beauloye, Christophe, Balligand, Jean-Luc
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.07.2017
• Subjects: Adult; Cells, Cultured; Cohort Studies; Contraceptive Agents - adverse effects; Contraceptive Agents - therapeutic use; Contraceptives; Cross-Sectional Studies; Drug-Related Side Effects and Adverse Reactions - metabolism; Electron Paramagnetic Resonance; Electron Spin Resonance Spectroscopy; Endothelial function; Endothelium, Vascular - pathology; Erythrocytes - metabolism; Ethinyl Estradiol - adverse effects; Ethinyl Estradiol - therapeutic use; Female; Glycated Hemoglobin A - metabolism; Heme-nitrosylated hemoglobin; Humans; Nitric Oxide - metabolism; Oxidation-Reduction; Oxidative Stress; Peroxides - blood; Progesterone Congeners - adverse effects; Progesterone Congeners - therapeutic use; Reactive hyperemia response; Vascular oxidative status; Venous Thromboembolism - etiology; Venous Thromboembolism - metabolism; Young Adult; Heme-nitrosylated hemoglobin; Vascular oxidative status; Reactive hyperemia response; Contraceptives; Endothelial function; Electron Paramagnetic Resonance

An increased risk of venous thromboembolism was identified in young women consuming combined contraceptive pills (CP) suggesting a disturbance of vascular homeostasis but the impact of CP on endothelial function and redox status of the vasculature was not thoroughly analyzed. We measured the bioavai...