Encapsulation of tDodSNO generates a photoactivated nitric oxide releasing nanoparticle for localized control of vasodilation and vascular hyperpermeability

• Published in: Free radical biology & medicine Vol. 130; pp. 297 - 305
• Main Authors: Alimoradi, Houman, Barzegar-Fallah, Anita, Sammut, Ivan A., Greish, Khaled, Giles, Gregory I.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.01.2019
• Subjects: Animals; Aorta - cytology; Aorta - drug effects; Capillary Permeability - drug effects; Cardiovascular Diseases - drug therapy; Cardiovascular Diseases - metabolism; Cardiovascular Diseases - pathology; Controlled release; Drug; Drug Delivery Systems; Drug Liberation; Humans; Hyperpermeability; Macromolecule; Maleic Anhydrides - chemistry; Maleic Anhydrides - pharmacology; Nanoparticles - chemistry; Nitric oxide; Nitric Oxide - metabolism; Nitroprusside - pharmacology; Photoactivation; Polymers - chemistry; Polymers - pharmacology; Rats; S-Nitroso-N-Acetylpenicillamine - pharmacology; S-nitrosothiol; S-Nitrosothiols - chemistry; S-Nitrosothiols - pharmacology; Solubility - drug effects; Vasodilation; Vasodilation - drug effects; Water - chemistry; NO; NP; RT; Hyperpermeability; EBD; ddH2O; GSNO; sGC; Vasodilation; BSA; SNP; SNT; EC50; HPLC; Controlled release; Drug; Photoactivation; SMA; KH buffer; tDodSNO; SNAP; PE; Macromolecule; Nitric oxide; KH-I; S-nitrosothiol

We report the synthesis and characterization of a photoactive nitric oxide (NO) releasing nanoparticle (NP) by encapsulation of the NO donor tert-dodecane S-nitrosothiol (tDodSNO) into a co-polymer of styrene and maleic anhydride (SMA) to afford SMA-tDodSNO. Encapsulation did not affect tDodSNO'...