NGF, BDNF, and NO in Myopic Subjects: Relationships Between Aqueous Levels and Lens Epithelial Cells’ Activation

• Published in: International journal of molecular sciences Vol. 26; no. 13; p. 6350
• Main Authors: De Piano, Maria, Cacciamani, Andrea, Scarinci, Fabio, Squitti, Rosanna, Cosimi, Pamela, Bruno, Marisa, Ripandelli, Guido, Palanza, Paola, Micera, Alessandra
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 01.07.2025
• Subjects: Adult; Aged; Aged, 80 and over; Antioxidants; Aqueous Humor - metabolism; Biomarkers; Biomarkers - metabolism; Brain-derived neurotrophic factor; Brain-Derived Neurotrophic Factor - genetics; Brain-Derived Neurotrophic Factor - metabolism; Cataract; Cataracts; Chronic diseases; Development and progression; Enzymes; Epigenesis, Genetic; Epigenetic inheritance; Epigenetics; Epithelial Cells - metabolism; Epithelial Cells - pathology; Female; Genes; Growth factors; Humans; Inflammation; Kinases; Lens, Crystalline - metabolism; Lens, Crystalline - pathology; Male; Metabolism; Metabolites; Middle Aged; Myopia; Myopia - genetics; Myopia - metabolism; Myopia - pathology; Nerve Growth Factor - genetics; Nerve Growth Factor - metabolism; Nitric oxide; Oxidative Stress; Proteins; Retina; Surgery; United States; Italy; California; NO; BDNF; stressful effectors; myopia; neurodegeneration; LEC; NGF

Several soluble mediators are activated during myogenesis and progression, and severe neurodegeneration, with related biomarkers, characterizes high myopia-related retinal atrophy. Targets of oxidative stress, epigenetics and neurogenic inflammation have been reported in the prospecting of some bioi...