Polygenic Scores of Alzheimer's Disease Risk Genes Add Only Modestly to APOE in Explaining Variation in Amyloid PET Burden

• Published in: Journal of Alzheimer's disease Vol. 88; no. 4; p. 1615
• Main Authors: Ramanan, Vijay K, Heckman, Michael G, Przybelski, Scott A, Lesnick, Timothy G, Lowe, Val J, Graff-Radford, Jonathan, Mielke, M, Jack, Clifford R, Knopman, David S, Petersen, Ronald C, Ross, Owen A, Vemuri, Prashanthi
• Format: Journal Article
• Language: English
• Published: United States 01.01.2022
• Subjects: Aged; Alzheimer Disease - diagnostic imaging; Alzheimer Disease - genetics; Amyloid - genetics; Amyloid beta-Peptides - genetics; Amyloidosis; Apolipoproteins E - genetics; Biomarkers; Genome-Wide Association Study; Humans; Multifactorial Inheritance; Positron-Emission Tomography; amyloid; Alzheimer’s disease; positron emission tomography; Apolipoprotein E; polygenic risk scores

Brain accumulation of amyloid-β is a hallmark event in Alzheimer's disease (AD) whose underlying mechanisms are incompletely understood. Case-control genome-wide association studies have implicated numerous genetic variants in risk of clinically diagnosed AD dementia. To test for associations b...