Disturbance of endogenous hydrogen sulfide generation and endoplasmic reticulum stress in hippocampus are involved in homocysteine-induced defect in learning and memory of rats

• Published in: Behavioural brain research Vol. 262; pp. 35 - 41
• Main Authors: Li, Man-Hong, Tang, Ji-Ping, Zhang, Ping, Li, Xiang, Wang, Chun-Yan, Wei, Hai-Jun, Yang, Xue-Feng, Zou, Wei, Tang, Xiao-Qing
• Format: Journal Article
• Language: English
• Published: Shannon Elsevier B.V 01.04.2014; Elsevier
• Subjects: Animals; Behavioral psychophysiology; Biological and medical sciences; Cystathionine beta-Synthase - metabolism; Endoplasmic Reticulum - drug effects; Endoplasmic Reticulum - metabolism; Endoplasmic Reticulum Stress; Fundamental and applied biological sciences. Psychology; Hippocampus - drug effects; Hippocampus - metabolism; Homocysteine; Homocysteine - administration & dosage; Homocysteine - toxicity; Hydrogen sulfide; Hydrogen Sulfide - metabolism; Infusions, Intraventricular; Learning and memory; Male; Maze Learning - drug effects; Memory - drug effects; Morris water maze; Novel object recognition test; Psychology. Psychoanalysis. Psychiatry; Psychology. Psychophysiology; Rats; Rats, Sprague-Dawley; Recognition (Psychology) - drug effects; Vertebrates: nervous system and sense organs; Hydrogen sulfide; Learning and memory; Morris water maze; Novel object recognition test; Homocysteine; Endoplasmic reticulum stress; Rat; Memory; Rodentia; Central nervous system; Cognition; Space perception; Novelty stimulus; Stress; Encephalon; Vertebrata; Mammalia; Acquisition process; Homocystein; Animal; Perceptive learning; Endoplasmic reticulum; Hippocampus; Recognition

•Exposure of rats to homocysteine (Hcy) leads to learning and memory dysfunctions.•Hcy decreases the generation of endogenous H2S in the hippocampus of rats.•Hcy up-regulates the endoplasmic reticulum (ER) stress in the hippocampus of rats.•Disturbed H2S formation and ER stress involve in Hcy-caused...