Novel Herbal Medicine C-KOK Suppresses the Inflammatory Gene iNOS via the Inhibition of p-STAT-1 and NF-κB

• Published in: Biotechnology and bioprocess engineering Vol. 25; no. 4; pp. 536 - 542
• Main Authors: Lee, In-Chul, Ryu, Chang-Woo, Bae, Jong-Sup
• Format: Journal Article
• Language: English
• Published: Seoul The Korean Society for Biotechnology and Bioengineering 01.08.2020; Springer Nature B.V; 한국생물공학회
• Subjects: animal models; anti-inflammatory activity; Antioxidants; Biotechnology; Chemistry; Chemistry and Materials Science; Cyclooxygenase-2; Cytokines; Cytosol; Endothelial cells; enzyme inhibition; genes; Heme; heme oxygenase (biliverdin-producing); Heme oxygenase (decyclizing); Herbal medicine; herbal medicines; humans; IL-1β; inducible nitric oxide synthase; Industrial and Production Engineering; interleukin-1beta; Lipopolysaccharides; Lung diseases; lungs; mice; NF-κB protein; Nitric oxide; Nitric-oxide synthase; Oriental traditional medicine; Oxygenase; prostaglandin synthase; Pulmonary arteries; Pulmonary artery; Regulatory sequences; Research Paper; respiratory tract diseases; response elements; RNA interference; RNA-mediated interference; Stat1 protein; transcription factor NF-kappa B; Translocation; tumor necrosis factor-alpha; Tumor necrosis factor-TNF; Tumor necrosis factor-α; 생물공학; C-KOK; endothelium; iNOS; p-STAT-1

Cheong-Pye-Ko (CPK) and Kyung-Ok-Ko (KOK) are traditional herbal medicine prescriptions that have been used in oriental medicine as tonics for pulmonary-related diseases for centuries. However, the effects of a mixture of CPK and KOK (C-KOK) on cytokine-mediated pulmonary damage have not yet been el...