Circulating Inflammatory Markers Are Associated With Magnetic Resonance Imaging-Visible Perivascular Spaces But Not Directly With White Matter Hyperintensities

• Published in: Stroke (1970) Vol. 45; no. 2; pp. 605 - 607
• Main Authors: ARIBISALA, Benjamin S, WISEMAN, Stewart, DEARY, Ian J, WARDLAW, Joanna M, MORRIS, Zoe, VALDES-HERNANDEZ, Maria C, ROYLE, Natalie A, MANIEGA, Susana M, GOW, Alan J, CORLEY, Janie, BASTIN, Mark E, STARR, John
• Format: Journal Article
• Language: English
• Published: Hagerstown, MD Lippincott Williams & Wilkins 01.02.2014
• Subjects: Aged; Algorithms; Biological and medical sciences; Biomarkers - blood; Brain - pathology; C-Reactive Protein - analysis; Cerebral Small Vessel Diseases - blood; Cerebral Small Vessel Diseases - pathology; Cohort Studies; Female; Fibrinogen - analysis; Humans; Image Processing, Computer-Assisted; Inflammation - blood; Interleukin-6 - blood; Investigative techniques, diagnostic techniques (general aspects); Magnetic Resonance Imaging; Male; Medical sciences; Nervous system; Neurology; Radiodiagnosis. Nmr imagery. Nmr spectrometry; Vascular diseases and vascular malformations of the nervous system; Stroke; Nervous system diseases; Senescence; magnetic resonance imaging; leukoencephalopathies; Cardiovascular disease; Inflammation; Leucoencephalopathy; Nuclear magnetic resonance imaging; White matter; Cerebral disorder; Vascular disease; Central nervous system disease; Medical imagery; Leucoaraïosis; aging; leukoaraiosis; Hyperintensity; Cerebrovascular disease; inflammation

White matter hyperintensities (WMH) and perivascular spaces (PVS) are features of small vessel disease, found jointly on MRI of older people. Inflammation is a prominent pathological feature of small vessel disease. We examined the association between inflammation, PVS, and WMH in the Lothian Birth...