Platelet-Leukocyte Activation during Hemodialysis Detected with a Monoclonal Antibody to Leukocyte Integrin CD11b

• Published in: Nephron Vol. 80; no. 2; pp. 197 - 203
• Main Authors: Hernández, M.R., Galán, A.M., Lozano, M., Bozzo, J., Cases, A., Escolar, G., Calls, J., Ordinas, A.
• Format: Journal Article
• Language: English
• Published: Basel, Switzerland S. Karger AG 01.10.1998
• Subjects: Aged; Aged, 80 and over; Antibodies, Monoclonal; Antigens, CD - blood; Biomarkers - blood; Blood Donors; Case-Control Studies; Female; Flow Cytometry - methods; Humans; Leukocytes - immunology; Macrophage-1 Antigen - blood; Male; Middle Aged; Original Paper; Platelet Activation; Platelet Aggregation - immunology; Receptors, Cell Surface - blood; Renal Dialysis; Reproducibility of Results; Uremia - immunology; Hemodialysis; Heterotypic aggregates; CD11b; Cross-talk

Platelet activation is commonly monitored with a battery of monoclonal antibodies against different platelet epitopes with controversial results. The transient expression of platelet markers and their role mediating interactions with other cells could easily explain these discrepancies. The present...