Inflammation in amyotrophic lateral sclerosis spinal cord and brain is mediated by activated macrophages, mast cells and T cells

• Published in: Amyotrophic lateral sclerosis and other motor neuron disorders Vol. 5; no. 4; pp. 213 - 219
• Main Authors: Graves, Michael, Fiala, Milan, Dinglasan, Lu Anne, Liu, Nancy, Sayre, James, Chiappelli, Francesco, van Kooten, Cees, Vinters, Harry
• Format: Journal Article
• Language: English
• Published: England Taylor & Francis 01.12.2004
• Subjects: adaptive immunity; Aged; Aged, 80 and over; Amyotrophic Lateral Sclerosis - immunology; Amyotrophic Lateral Sclerosis - metabolism; Amyotrophic Lateral Sclerosis - pathology; Brain - immunology; Brain - metabolism; Brain - pathology; Cyclooxygenase 2; Humans; immunopathogenesis of ALS; inflammation; innate immunity; Macrophages - immunology; Macrophages - metabolism; mast cells; Mast Cells - immunology; Mast Cells - metabolism; Membrane Proteins; Middle Aged; Prostaglandin-Endoperoxide Synthases - biosynthesis; Spinal Cord - immunology; Spinal Cord - metabolism; Spinal Cord - pathology; T-Lymphocytes - immunology; T-Lymphocytes - metabolism

Recent studies have shown inflammatory markers in affected neural tissues of amyotrophic lateral sclerosis (ALS) patients. We examined immunocytochemically spinal cord tissues of six patients with ALS, two with corticospinal tract degeneration secondary to cerebral infarcts and three control subject...