Vascular peroxidase 1 mediates hypoxia-induced pulmonary artery smooth muscle cell proliferation, apoptosis resistance and migration

• Published in: Cardiovascular research Vol. 114; no. 1; pp. 188 - 199
• Main Authors: You, Baiyang, Liu, Yanbo, Chen, Jia, Huang, Xiao, Peng, Huihui, Liu, Zhaoya, Tang, Yixin, Zhang, Kai, Xu, Qian, Li, Xiaohui, Cheng, Guangjie, Shi, Ruizheng, Zhang, Guogang
• Format: Journal Article
• Language: English
• Published: England Oxford University Press 01.01.2018
• Subjects: Animals; Apoptosis; Apoptosis Regulatory Proteins - metabolism; Cell Cycle Proteins - metabolism; Cell Hypoxia; Cell Movement; Cell Proliferation; Cells, Cultured; Disease Models, Animal; Hemeproteins - metabolism; Hypertension, Pulmonary - enzymology; Hypertension, Pulmonary - etiology; Hypertension, Pulmonary - pathology; Hypochlorous Acid - metabolism; Hypoxia - complications; Hypoxia - enzymology; Male; Matrix Metalloproteinase 2 - metabolism; Matrix Metalloproteinase 9 - metabolism; Muscle, Smooth, Vascular - enzymology; Muscle, Smooth, Vascular - pathology; Myocytes, Smooth Muscle - enzymology; Myocytes, Smooth Muscle - pathology; NADPH Oxidase 4 - metabolism; NF-kappa B - metabolism; Peroxidases - metabolism; Pulmonary Artery - enzymology; Pulmonary Artery - pathology; Rats, Sprague-Dawley; Signal Transduction; Vascular Remodeling; NF-κB; Hypoxia; Vascular peroxidase 1; Pulmonary vascular remodelling; Pulmonary artery smooth muscle cells

Abstract Aims Reactive oxygen species (ROS) play essential roles in the pulmonary vascular remodelling associated with hypoxia-induced pulmonary hypertension (PH). Vascular peroxidase 1 (VPO1) is a newly identified haeme-containing peroxidase that accelerates oxidative stress development in the vasc...