Panax notoginseng saponins modulate the gut microbiota to promote thermogenesis and beige adipocyte reconstruction via leptin-mediated AMPKα/STAT3 signaling in diet-induced obesity

• Published in: Theranostics Vol. 10; no. 24; pp. 11302 - 11323
• Main Authors: Xu, Yu, Wang, Ning, Tan, Hor-Yue, Li, Sha, Zhang, Cheng, Zhang, Zhangjin, Feng, Yibin
• Format: Journal Article
• Language: English
• Published: Wyoming Ivyspring International Publisher Pty Ltd 01.01.2020; Ivyspring International Publisher
• Subjects: Adipocytes; Body fat; Diet; Energy; Glucose; Insulin; Medical research; Metabolism; Metabolites; Microbiota; Monitoring systems; Obesity; Proteins; Research Paper; Thermogenesis; Triglycerides

Background: Activation of the thermogenic program in white and brown adipocytes presents a promising avenue for increasing energy expenditure during the treatment of obesity. The endogenous mechanism for promoting thermogenesis in brown adipocytes or browning in white adipocytes has indicated that t...