Cancer Therapy by Catechins Involves Redox Cycling of Copper Ions and Generation of Reactive Oxygen Species

• Published in: Toxins Vol. 8; no. 2; p. 37
• Main Authors: Farhan, Mohd, Khan, Husain, Oves, Mohammad, Al-Harrasi, Ahmed, Rehmani, Nida, Arif, Hussain, Hadi, Sheikh, Ahmad, Aamir
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI 04.02.2016; MDPI AG
• Subjects: anticancer; Antineoplastic Agents - pharmacology; Antineoplastic Agents - therapeutic use; Catechin - analogs & derivatives; Catechin - pharmacology; Catechin - therapeutic use; catechins; Cell Line, Tumor; Cell Proliferation - drug effects; Comet Assay; copper; Copper - metabolism; DNA - metabolism; DNA breakage; DNA Damage; epicatechin; epigallocatechin; epigallocatechin-3-gallate; Humans; Hydroxyl Radical - metabolism; Lymphocytes - drug effects; Lymphocytes - metabolism; Neoplasms - drug therapy; Oxidation-Reduction; prooxidant; reactive oxygen species; Superoxides - metabolism; Thiobarbituric Acid Reactive Substances - metabolism; epigallocatechin-3-gallate; catechins; DNA breakage; reactive oxygen species; copper; epicatechin; prooxidant; anticancer; epigallocatechin

Catechins, the dietary phytochemicals present in green tea and other beverages, are considered to be potent inducers of apoptosis and cytotoxicity to cancer cells. While it is believed that the antioxidant properties of catechins and related dietary agents may contribute to lowering the risk of canc...