Promoter Hypermethylation Is the Predominant Mechanism in hMLH1 and hMSH2 Deregulation and Is a Poor Prognostic Factor in Nonsmoking Lung Cancer - Hsu, Han-Shui; Wen, Chiao-Kai; Tang, Yen-An; Lin, Ruo-Kai; Li, Wing-Yin; Hsu, Wen-Hu; Wang, Yi-Ching (Clinical cancer research, 2005)
Keywords: Adult; Aged; Antineoplastic agents; Biological and medical sciences; Carcinoma, Non-Small-Cell Lung - diagnosis; Carcinoma, Non-Small-Cell Lung - genetics; DNA Methylation; DNA Restriction Enzymes - chemistry; DNA Restriction Enzymes - pharmacology; Female; gene; Gene Expression Regulation, Neoplastic; hMLH1; hMSH2; Humans; Immunohistochemistry; Lung Neoplasms - diagnosis; Lung Neoplasms - genetics; Medical sciences; Middle Aged; Neoplasm Metastasis; NSCLC; Pharmacology. Drug treatments; Pneumology; Polymerase Chain Reaction; Prognosis; promoter hypermethylation; Promoter Regions, Genetic; Smoking; Time Factors; Treatment Outcome; Tumors of the respiratory system and mediastinum; Lung disease; Prognosis; Respiratory disease; Transcription promoter; Lung cancer; Mechanism of action; Methylation; Bronchopulmonary; Repair gene