Total body irradiation and syngeneic marrow transplantation in an inbred rat model of acute myelogenous leukemia

While acute myelogenous leukemia (AML) occurs rarely in laboratory animals, over 20 model systems have been reported. One of these, AML of the inbred Wistar/Furth Rat, has been shown to be pathophysiologically similar to human AML. Ten days after intravenous inoculation of 1.0 × 10 6 cells of a tiss...

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Published inInternational journal of radiation oncology, biology, physics Vol. 4; no. 5; pp. 421 - 427
Main Authors Greenberger, Joel S., Lockwood, Charles J., France, Dennis S., McGrath, Thomas, Moloney, William C.
Format Journal Article
LanguageEnglish
Published United States Elsevier Inc 01.01.1978
Subjects
Animals
Bone Marrow - drug effects
Bone Marrow - radiation effects
Bone Marrow Transplantation
Busulfan - pharmacology
Cyclophosphamide - pharmacology
Disease Models, Animal
Leukemia, Experimental - blood
Leukemia, Experimental - therapy
Leukemia, Myeloid, Acute - blood
Leukemia, Myeloid, Acute - therapy
Leukocyte Count
Rat acute myelogenous leukemia
Rats
Rats, Inbred WF
Recurrence
Total body irradiation
Transplantation, Isogeneic
Bone marrow transplantation
Rat acute myelogenous leukemia
Total body irradiation
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Abstract While acute myelogenous leukemia (AML) occurs rarely in laboratory animals, over 20 model systems have been reported. One of these, AML of the inbred Wistar/Furth Rat, has been shown to be pathophysiologically similar to human AML. Ten days after intravenous inoculation of 1.0 × 10 6 cells of a tissue culture grown clonal line, rats demonstrated peripheral blood leukemia, replacement of greater than 90% of the bone marrow with distinctive malignant myeloblasts and a syndrome of hypermuramidase (lysozyme) emia and muramidasuria. Total body irradiation (TBI) at 10 days after leukemia cell passage with a marrow lethal dose (950 rad, 140 rad/min, 137Cs source, 663 kV) followed by intravenous inoculation of 5.0 × 10 8/kg viable syngeneic bone marrow cells produced transient complete remissions. Repopulation with transplanted marrow was detected along with increasing numbers of recognizable W Fu AML cells in peripheral blood, marrow and central nervous system. The delayed leukemia relapse in irradiated transplanted rats compared to irradiated non-transplanted controls suggests an interaction between surviving W Fu AML cells and transplanted marrow. This model may be of value in studies designing a therapeutic interaction against AML by donor marrow in the chemotherapy, immunotherapy, and total body irradiated patient.
AbstractList While acute myelogenous leukemia (AML) occurs rarely in laboratory animals, over 20 model systems have been reported. One of these, AML of the inbred Wistar/Furth Rat, has been shown to be pathophysiologically similar to human AML. Ten days after intravenous inoculation of 1.0 × 10 6 cells of a tissue culture grown clonal line, rats demonstrated peripheral blood leukemia, replacement of greater than 90% of the bone marrow with distinctive malignant myeloblasts and a syndrome of hypermuramidase (lysozyme) emia and muramidasuria. Total body irradiation (TBI) at 10 days after leukemia cell passage with a marrow lethal dose (950 rad, 140 rad/min, 137Cs source, 663 kV) followed by intravenous inoculation of 5.0 × 10 8/kg viable syngeneic bone marrow cells produced transient complete remissions. Repopulation with transplanted marrow was detected along with increasing numbers of recognizable W Fu AML cells in peripheral blood, marrow and central nervous system. The delayed leukemia relapse in irradiated transplanted rats compared to irradiated non-transplanted controls suggests an interaction between surviving W Fu AML cells and transplanted marrow. This model may be of value in studies designing a therapeutic interaction against AML by donor marrow in the chemotherapy, immunotherapy, and total body irradiated patient.
Author Greenberger, Joel S.
Lockwood, Charles J.
France, Dennis S.
Moloney, William C.
McGrath, Thomas
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Keywords Bone marrow transplantation
Rat acute myelogenous leukemia
Total body irradiation
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Snippet While acute myelogenous leukemia (AML) occurs rarely in laboratory animals, over 20 model systems have been reported. One of these, AML of the inbred...
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elsevier
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StartPage 421
SubjectTerms Animals
Bone Marrow - drug effects
Bone Marrow - radiation effects
Bone Marrow Transplantation
Busulfan - pharmacology
Cyclophosphamide - pharmacology
Disease Models, Animal
Leukemia, Experimental - blood
Leukemia, Experimental - therapy
Leukemia, Myeloid, Acute - blood
Leukemia, Myeloid, Acute - therapy
Leukocyte Count
Rat acute myelogenous leukemia
Rats
Rats, Inbred WF
Recurrence
Total body irradiation
Transplantation, Isogeneic
Title Total body irradiation and syngeneic marrow transplantation in an inbred rat model of acute myelogenous leukemia
URI https://dx.doi.org/10.1016/0360-3016(78)90072-X
https://www.ncbi.nlm.nih.gov/pubmed/357356
Volume 4
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