Should Race-Genotype Interactions Be Considered in the Global Development of CYP2C19 Substrates? A Proposed Framework Using Physiologically Based Pharmacokinetic Modeling - Patel, Chirag; Rathi, Chetan; Venkatakrishnan, Karthik (Journal of clinical pharmacology, 2017)
Keywords: Continental Population Groups - genetics; Cytochrome P-450 CYP2C19 - genetics; Cytochrome P-450 CYP2C19 - metabolism; Cytochrome P-450 CYP2C19 Inducers - metabolism; Cytochrome P-450 CYP2C19 Inducers - pharmacology; Cytochrome P-450 CYP2C19 Inhibitors - metabolism; Cytochrome P-450 CYP2C19 Inhibitors - pharmacology; Drug Discovery - methods; Drug Discovery - trends; Genotype; Humans; Models, Biological; Substrate Specificity - drug effects; Substrate Specificity - physiology; PBPK; race; CYP2C19; genetic polymorphism; physiologically based pharmacokinetic modeling; genotype