Detection of local DNA copy number changes in lung cancer population analyses using a multi-scale approach

• Published in: Communication in statistics. Case studies and data analysis Vol. 1; no. 4; pp. 206 - 216
• Main Authors: Kachouie, Nezamoddin N., Lin, Xihong, Christiani, David C., Schwartzman, Armin
• Format: Journal Article
• Language: English
• Published: United States Taylor & Francis 02.10.2015
• Subjects: Copy number alterations (CNAs); gene-cancer association; local region detection; lung cancer; Copy number alterations (CNAs); Local region detection; Gene-Cancer association; Lung cancer

Emerging advances in genomic sequencing have prompted the development of new computational methods for studying the genomic sources of human diseases. This article presents a recent statistical approach for detection of local regions with significant copy number alterations (CNAs) in a population of...