Liquid–liquid phase separation drives the β‐catenin destruction complex formation

• Published in: BioEssays Vol. 43; no. 10; pp. e2100138 - n/a
• Main Authors: Shi, Qiaoni, Kang, Kexin, Chen, Ye‐Guang
• Format: Journal Article
• Language: English
• Published: Cambridge Wiley Subscription Services, Inc 01.10.2021
• Subjects: APC; Axin; biomolecular condensate; Catenin; Complex formation; Destruction; destruction complex; Inactivation; Liquid phases; LLPS; Phase separation; separation; Signaling; signalosome; Transcription activation; transcriptional activation; Wnt protein; Wnt signaling

The intracellular multiprotein complex β‐catenin destruction complex plays a key role in Wnt/β‐catenin signaling. Wnt stimulation induces the assembly of the receptor‐associated signalosome and the inactivation of the destruction complex, leading to β‐catenin accumulation and transcriptional activat...