Integrated mRNA and microRNA profiling in lung tissue and blood from human silicosis

• Published in: The journal of gene medicine Vol. 25; no. 8; pp. e3518 - n/a
• Main Authors: Zhang, Jingbo, Hu, Weijiang, Liu, Kai, Liu, Jie, Zheng, Yuxin, Sun, Xin, Mei, Liangying, Qian, Zushu, Sun, Qiangguo, Liu, Qiang, Wu, Zhijun, Zhang, Hengdong, Li, Yanping, Sun, Daoyuan, Ye, Meng
• Format: Journal Article
• Language: English
• Published: England Wiley Periodicals Inc 01.08.2023
• Subjects: Biomarkers; Bisulfite; DNA microarrays; Gene expression; Gene therapy; lung fibrosis; Lungs; MicroRNAs; miRNA; PTEN protein; Silicosis; transcription; Transcriptomes; silicosis; transcription; lung fibrosis

Background The overwhelming majority of subjects in the current silicosis mRNA and microRNA (miRNA) expression profile are of human blood, lung cells or a rat model, which puts limits on the understanding of silicosis pathogenesis and therapy. To address the limitations, our investigation was focuse...