7 tricks for 7 T CEST: Improving the reproducibility of multipool evaluation provides insights into the effects of age and the early stages of Parkinson's disease

• Published in: NMR in biomedicine Vol. 36; no. 6; pp. e4717 - n/a
• Main Authors: Mennecke, Angelika, Khakzar, Katrin M., German, Alexander, Herz, Kai, Fabian, Moritz S., Liebert, Andrzej, Blümcke, Ingmar, Kasper, Burkhard S., Nagel, Armin M., Laun, Frederik B., Schmidt, Manuel, Winkler, Jürgen, Dörfler, Arnd, Zaiss, Moritz
• Format: Journal Article
• Language: English
• Published: England Wiley Subscription Services, Inc 01.06.2023
• Subjects: 7 T; age; Age differences; Age factors; Aliphatic compounds; amide; Amides; Amplitudes; Biological products; Brain; CEST; Coefficient of variation; Humans; Interpolation; Lorentzian fitting; Magnetic Resonance Imaging - methods; Movement disorders; Neurodegenerative diseases; Neuroimaging; Noise reduction; Optimization; Overhauser effect; Parkinson; Parkinson Disease - diagnostic imaging; Parkinson's disease; Principal components analysis; Reproducibility; Reproducibility of Results; rNOE; Smoothing; standardization; Substantia nigra; amide; 7 T; Lorentzian fitting; rNOE; standardization; CEST; Parkinson; age

The objective of the current study was to optimize the postprocessing pipeline of 7 T chemical exchange saturation transfer (CEST) imaging for reproducibility and to prove this optimization for the detection of age differences and differences between patients with Parkinson's disease versus nor...