C3 Sulfenylation of N‐Heteroarenes in Water under Catalyst‐Free Conditions

• Published in: European journal of organic chemistry Vol. 2017; no. 25; pp. 3646 - 3651
• Main Authors: Ravi, Chitrakar, Joshi, Abhisek, Adimurthy, Subbarayappa
• Format: Journal Article
• Language: English
• Published: WEINHEIM Wiley 07.07.2017; Wiley Subscription Services, Inc
• Subjects: Catalyst free; Catalysts; Chemistry; Chemistry, Organic; C–H functionalization; Feasibility studies; Heterocycles; Hogs; Indoles; Physical Sciences; Pyridines; Science & Technology; Sulfur; Water chemistry; SYSTEM; Heterocycles; Water chemistry; ARYL SULFONYL HYDRAZIDES; Catalyst-free; REGIOSELECTIVE SULFENYLATION; HYDROAMINATION; C-H functionalization; H BOND FUNCTIONALIZATION; INDOLES; ELEMENTAL SULFUR; Sulfur; THIOSULFONATES; SULPHENYLATION; IMIDAZOHETEROCYCLES

A method for the catalyst‐free C–H sulfenylation of imidazo[1,2‐a]pyridines by using sulfonothioates as an odorless thioarylated reagent in aqueous medium was developed. This protocol was used for a variety of substituted imidazo[1,2‐a]pyridines with broad functional‐group tolerance and was extended...