Synthesis of 2‐Oxindoles from Substituted Indoles by Hypervalent‐Iodine Oxidation

• Published in: European journal of organic chemistry Vol. 2018; no. 12; pp. 1437 - 1442
• Main Authors: Jiang, Xinpeng, Zheng, Cong, Lei, Lijun, Lin, Kai, Yu, Chuanming
• Format: Journal Article
• Language: English
• Published: WEINHEIM Wiley 29.03.2018; Wiley Subscription Services, Inc
• Subjects: Chemistry; Chemistry, Organic; Hypervalent compounds; Indoles; Iodine; Nitrogen heterocycles; Oxidation; Parkinson's disease; Physical Sciences; Reagents; Science & Technology; Substitutes; Synthesis; DESIGN; REAGENTS; ONE-POT SYNTHESIS; Hypervalent compounds; OXINDOLES; KINASE INHIBITORS; DISCOVERY; Nitrogen heterocycles; ASSIGNMENT; Oxidation; Indoles; DERIVATIVES; Iodine

A practical conversion of indoles into the corresponding 2‐oxindoles is achieved efficiently using a hypervalent iodine reagent. This oxidation is amenable to different substituted indoles, and allows the synthesis of a wide range of synthetically valuable substituted 2‐oxindoles in up to 90 % yield...