Amide‐phosphonium Salt Catalyzed Enantioselective Vinylogous Mannich Addition of Coumarins to Isatin Imines

• Published in: ChemCatChem Vol. 12; no. 2; pp. 444 - 448
• Main Authors: Wang, Jing, Zhang, Shuo, Ding, Weizhong, Wang, Chenghan, Chen, Jie, Cao, Weiguo, Wu, Xiaoyu
• Format: Journal Article
• Language: English
• Published: Weinheim Wiley Subscription Services, Inc 18.01.2020
• Subjects: Adducts; Asymmetric; Coumarin; Enantiomers; Imines; Mannich reaction; Oxindole; Vinylogous

An asymmetric vinylogous Mannich reaction between 3‐cyano‐4‐methylcoumarins and N‐Boc isatin imines catalysed by amide phosphonium salt is described. This method allows the formation of intriguing adducts bearing both 3‐aminooxindole and coumarin moieties in excellent yields with excellent enantiose...