Epiproteome profiling of cadmium‐transformed human bronchial epithelial cells by quantitative histone post‐translational modification–enzyme‐linked immunosorbent assay

• Published in: Journal of applied toxicology Vol. 38; no. 6; pp. 888 - 895
• Main Authors: Liang, Zhan‐Ling, Wu, Dan‐Dan, Yao, Yue, Yu, Fei‐Yuan, Yang, Lei, Tan, Heng Wee, Hylkema, Machteld N., Rots, Marianne G., Xu, Yan‐Ming, Lau, Andy T. Y.
• Format: Journal Article
• Language: English
• Published: England Wiley Subscription Services, Inc 01.06.2018
• Subjects: Acetylation; Airborne particulates; Antibodies; Bronchi - drug effects; Bronchi - metabolism; Bronchi - pathology; Cadmium; Cadmium chloride; Cadmium Chloride - toxicity; Carcinogens; Cell Line; Cell migration; Cell Movement - drug effects; Cell Proliferation - drug effects; cell transformation; Chronic exposure; ELISA; Enzyme Inhibitors - pharmacology; Enzyme-Linked Immunosorbent Assay; Enzymes; epiproteome; Epithelial cells; Epithelial Cells - drug effects; Epithelial Cells - metabolism; Epithelial Cells - pathology; Epithelial-Mesenchymal Transition - drug effects; Gene expression; histone; Histone acetyltransferase; Histone Acetyltransferases - antagonists & inhibitors; Histone Acetyltransferases - metabolism; Histones - metabolism; human lung cells; Humans; Interrogation; Lung diseases; Mesenchyme; Methylation; phosphorylation; post‐translational modifications; Protein Processing, Post-Translational - drug effects; Proteins; Proteomes; Proteomics - methods; Soil water; Transformed cells; Translation; acetylation; cell transformation; epiproteome; methylation; cadmium; human lung cells; histone; post-translational modifications; phosphorylation; ELISA

Cadmium (Cd), a carcinogenic toxic metal, is pervasively distributed in the soil, water and air. Chronic exposure to Cd has been correlated to lung disease development including cancers. Although many studies have been conducted to investigate the proteome response of cells challenged with Cd, the e...