Cardiovascular Disease: The Other Face of Diabetes

Despite glycemic control, evidence suggests that mortality and morbidity remain high in diabetes. Regulatory agencies deem, therefore, additional safety trials necessary for the approval of new antidiabetic drugs. Nevertheless, markers of cardiovascular risk, which can be used as response predictors...

Full description

Saved in:
Bibliographic Details
Published inCPT: pharmacometrics and systems pharmacology Vol. 2; no. 10; pp. 1 - 4
Main Authors Vlasakakis, G, Della Pasqua, O
Format Journal Article
LanguageEnglish
Published United States John Wiley & Sons, Inc 01.10.2013
Nature Publishing Group
Subjects
Biomarkers
Blood pressure
Cardiovascular disease
Diabetes
Glucose
Health risk assessment
Hemoglobin
Homeostasis
Hyperglycemia
Insulin resistance
Lipids
Lipoproteins
Metabolic syndrome
Mortality
Online AccessGet full text

Cover

Abstract Despite glycemic control, evidence suggests that mortality and morbidity remain high in diabetes. Regulatory agencies deem, therefore, additional safety trials necessary for the approval of new antidiabetic drugs. Nevertheless, markers of cardiovascular risk, which can be used as response predictors, are not available. In contrast with current efforts on further understanding of glucose–insulin homeostasis, a model‐based approach is required to assess the correlation between hyperglycemia and cardiometabolic phenotypes, enabling prediction of the underlying cardiovascular risk. CPT: Pharmacometrics & Systems Pharmacology (2013) 2, e81; doi:10.1038/psp.2013.57; advance online publication 23 October 2013
AbstractList Despite glycemic control, evidence suggests that mortality and morbidity remain high in diabetes. Regulatory agencies deem, therefore, additional safety trials necessary for the approval of new antidiabetic drugs. Nevertheless, markers of cardiovascular risk, which can be used as response predictors, are not available. In contrast with current efforts on further understanding of glucose–insulin homeostasis, a model‐based approach is required to assess the correlation between hyperglycemia and cardiometabolic phenotypes, enabling prediction of the underlying cardiovascular risk. CPT: Pharmacometrics & Systems Pharmacology (2013) 2, e81; doi:10.1038/psp.2013.57; advance online publication 23 October 2013
Despite glycemic control, evidence suggests that mortality and morbidity remain high in diabetes. Regulatory agencies deem, therefore, additional safety trials necessary for the approval of new antidiabetic drugs. Nevertheless, markers of cardiovascular risk, which can be used as response predictors, are not available. In contrast with current efforts on further understanding of glucose-insulin homeostasis, a model-based approach is required to assess the correlation between hyperglycemia and cardiometabolic phenotypes, enabling prediction of the underlying cardiovascular risk.CPT: Pharmacometrics & Systems Pharmacology (2013) 2, e81; doi:10.1038/psp.2013.57; advance online publication 23 October 2013.
Despite glycemic control, evidence suggests that mortality and morbidity remain high in diabetes. Regulatory agencies deem, therefore, additional safety trials necessary for the approval of new antidiabetic drugs. Nevertheless, markers of cardiovascular risk, which can be used as response predictors, are not available. In contrast with current efforts on further understanding of glucose–insulin homeostasis, a model‐based approach is required to assess the correlation between hyperglycemia and cardiometabolic phenotypes, enabling prediction of the underlying cardiovascular risk. CPT: Pharmacometrics & Systems Pharmacology (2013) 2, e81; doi: 10.1038/psp.2013.57 ; advance online publication 23 October 2013
Despite glycemic control, evidence suggests that mortality and morbidity remain high in diabetes. Regulatory agencies deem, therefore, additional safety trials necessary for the approval of new antidiabetic drugs. Nevertheless, markers of cardiovascular risk, which can be used as response predictors, are not available. In contrast with current efforts on further understanding of glucose–insulin homeostasis, a model-based approach is required to assess the correlation between hyperglycemia and cardiometabolic phenotypes, enabling prediction of the underlying cardiovascular risk.
Despite glycemic control, evidence suggests that mortality and morbidity remain high in diabetes. Regulatory agencies deem, therefore, additional safety trials necessary for the approval of new antidiabetic drugs. Nevertheless, markers of cardiovascular risk, which can be used as response predictors, are not available. In contrast with current efforts on further understanding of glucose–insulin homeostasis, a model‐based approach is required to assess the correlation between hyperglycemia and cardiometabolic phenotypes, enabling prediction of the underlying cardiovascular risk.CPT: Pharmacometrics & Systems Pharmacology (2013) 2, e81; doi:10.1038/psp.2013.57; advance online publication 23 October 2013
Author Della Pasqua, O
Vlasakakis, G
Author_xml – sequence: 1
  givenname: G
  surname: Vlasakakis
  fullname: Vlasakakis, G
  organization: Clinical Pharmacology Modelling and Simulation, GlaxoSmithKline, Stockley Park
– sequence: 2
  givenname: O
  surname: Della Pasqua
  fullname: Della Pasqua, O
  email: odp72514@gsk.com
  organization: University College London
BackLink https://www.ncbi.nlm.nih.gov/pubmed/24153424$$D View this record in MEDLINE/PubMed
BookMark eNp9kU1LAzEQhoNUbNWevMuCF0G25rO78SBItSoICtZzSLMTu2W7qUm30n9vSmtRD-aSgXl4Mpn3ELVqVwNCJwT3CGb55TzMexQT1hPZHupQ0mdpznC_9aNuo24IUxxPxjGR-AC1KSeCcco7iA60L0q31ME0lfbJbRlAB7hKRhNInhcT8MlQG0icjS09hgWEY7RvdRWgu72P0NvwbjR4SJ-e7x8HN0-pYTnLUqaZkEIQCraQHCz0jTQ2B8Iw55aJQuYWikwU1hDdJxIsGxugY6FzQ4zk7Ahdb7zzZjyDwkC98LpSc1_OtF8pp0v1u1OXE_XulorlJGNZFgXnW4F3Hw2EhZqVwUBV6RpcExThXEjCZS4jevYHnbrG1_F7ilIZt0YlJZG62FDGuxA82N0wBKt1HCrGodZxKLF-_vTn_Dv2e_kRYBvgs6xg9Z9Lvby-8HUdtV8cbZZb
CitedBy_id crossref_primary_10_7762_cnr_2014_3_2_89
crossref_primary_10_1007_s00228_017_2301_8
Cites_doi 10.2174/187153010791213119
10.1016/j.jfma.2011.10.003
10.1016/j.amjmed.2007.03.022
10.1038/psp.2013.30
10.1111/j.1547-5069.2012.01484.x
10.1016/S0140-6736(06)68967-8
10.1002/oby.20049
10.1016/S0140-6736(02)08090-X
10.1111/j.1467-985X.2007.00527.x
ContentType Journal Article
Copyright 2013 The Authors. CPT: Pharmacometrics & Systems Pharmacology published by Wiley Periodicals, Inc.
2013. This work is published under http://creativecommons.org/licenses/by-nc-nd/3.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.
Copyright © 2013 American Society for Clinical Pharmacology and Therapeutics 2013 American Society for Clinical Pharmacology and Therapeutics
Copyright_xml – notice: 2013 The Authors. CPT: Pharmacometrics & Systems Pharmacology published by Wiley Periodicals, Inc.
– notice: 2013. This work is published under http://creativecommons.org/licenses/by-nc-nd/3.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.
– notice: Copyright © 2013 American Society for Clinical Pharmacology and Therapeutics 2013 American Society for Clinical Pharmacology and Therapeutics
DBID 24P
WIN
NPM
AAYXX
CITATION
3V.
7X7
7XB
8FI
8FJ
8FK
ABUWG
AFKRA
AZQEC
BENPR
CCPQU
DWQXO
FYUFA
GHDGH
K9.
M0S
PIMPY
PQEST
PQQKQ
PQUKI
PRINS
7X8
5PM
DOI 10.1038/psp.2013.57
DatabaseName Wiley-Blackwell Open Access Collection
Wiley-Blackwell Backfiles (Open access)
PubMed
CrossRef
ProQuest Central (Corporate)
Health & Medical Collection
ProQuest Central (purchase pre-March 2016)
Hospital Premium Collection
Hospital Premium Collection (Alumni Edition)
ProQuest Central (Alumni) (purchase pre-March 2016)
ProQuest Central (Alumni)
ProQuest Central UK/Ireland
ProQuest Central Essentials
ProQuest Central
ProQuest One Community College
ProQuest Central
Health Research Premium Collection
Health Research Premium Collection (Alumni)
ProQuest Health & Medical Complete (Alumni)
Health & Medical Collection (Alumni Edition)
Publicly Available Content Database
ProQuest One Academic Eastern Edition (DO NOT USE)
ProQuest One Academic
ProQuest One Academic UKI Edition
ProQuest Central China
MEDLINE - Academic
PubMed Central (Full Participant titles)
DatabaseTitle PubMed
CrossRef
Publicly Available Content Database
ProQuest Central Essentials
ProQuest One Academic Eastern Edition
ProQuest Health & Medical Complete (Alumni)
ProQuest Central (Alumni Edition)
ProQuest One Community College
ProQuest Hospital Collection
Health Research Premium Collection (Alumni)
ProQuest Central China
ProQuest Hospital Collection (Alumni)
ProQuest Central
ProQuest Health & Medical Complete
Health Research Premium Collection
ProQuest One Academic UKI Edition
Health and Medicine Complete (Alumni Edition)
ProQuest Central Korea
ProQuest One Academic
ProQuest Central (Alumni)
MEDLINE - Academic
DatabaseTitleList
PubMed
CrossRef

Publicly Available Content Database
Database_xml – sequence: 1
  dbid: 24P
  name: Wiley Open Access
  url: https://authorservices.wiley.com/open-science/open-access/browse-journals.html
  sourceTypes: Publisher
– sequence: 2
  dbid: NPM
  name: PubMed
  url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed
  sourceTypes: Index Database
– sequence: 3
  dbid: 7X7
  name: Health & Medical Collection
  url: https://search.proquest.com/healthcomplete
  sourceTypes: Aggregation Database
DeliveryMethod fulltext_linktorsrc
Discipline Pharmacy, Therapeutics, & Pharmacology
EISSN 2163-8306
EndPage 4
ExternalDocumentID 10_1038_psp_2013_57
24153424
PSP4201357
Genre article
Journal Article
GroupedDBID 0R~
1OC
24P
5VS
7X7
8FI
8FJ
AAHHS
AAZKR
ABDBF
ABUWG
ACCFJ
ACGFS
ACXQS
ADBBV
ADKYN
ADRAZ
ADZMN
ADZOD
AEEZP
AEQDE
AFKRA
AIWBW
AJBDE
ALAGY
ALIPV
ALMA_UNASSIGNED_HOLDINGS
ALUQN
AOIJS
AVUZU
BAWUL
BCNDV
BENPR
BPHCQ
BVXVI
CCPQU
DIK
EBS
EJD
FYUFA
GODZA
GROUPED_DOAJ
GX1
HMCUK
HYE
IAO
IHR
INH
KQ8
M48
M~E
O9-
OK1
OVD
PIMPY
PQQKQ
PROAC
RNTTT
RPM
TEORI
TUS
UKHRP
WIN
NPM
AAYXX
CITATION
3V.
7XB
8FK
AZQEC
DWQXO
K9.
PQEST
PQUKI
PRINS
7X8
5PM
ID FETCH-LOGICAL-c3837-3a3595512efd94efe6c9cf8e13044f35d98fed75dfc1a619ef3bce2b5a8c1c943
IEDL.DBID RPM
ISSN 2163-8306
IngestDate Tue Sep 17 20:54:20 EDT 2024
Fri Jun 28 11:30:28 EDT 2024
Thu Oct 10 16:48:00 EDT 2024
Fri Aug 23 01:10:34 EDT 2024
Sat Sep 28 08:37:44 EDT 2024
Sat Aug 24 00:53:51 EDT 2024
IsDoiOpenAccess true
IsOpenAccess true
IsPeerReviewed true
IsScholarly true
Issue 10
Language English
License Attribution-NonCommercial-NoDerivs
LinkModel DirectLink
MergedId FETCHMERGED-LOGICAL-c3837-3a3595512efd94efe6c9cf8e13044f35d98fed75dfc1a619ef3bce2b5a8c1c943
Notes ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
OpenAccessLink https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3817377/
PMID 24153424
PQID 2290192921
PQPubID 4368367
PageCount 4
ParticipantIDs pubmedcentral_primary_oai_pubmedcentral_nih_gov_3817377
proquest_miscellaneous_1445914989
proquest_journals_2290192921
crossref_primary_10_1038_psp_2013_57
pubmed_primary_24153424
wiley_primary_10_1038_psp_2013_57_PSP4201357
PublicationCentury 2000
PublicationDate October 2013
PublicationDateYYYYMMDD 2013-10-01
PublicationDate_xml – month: 10
  year: 2013
  text: October 2013
PublicationDecade 2010
PublicationPlace United States
PublicationPlace_xml – name: United States
– name: Hoboken
PublicationTitle CPT: pharmacometrics and systems pharmacology
PublicationTitleAlternate CPT Pharmacometrics Syst Pharmacol
PublicationYear 2013
Publisher John Wiley & Sons, Inc
Nature Publishing Group
Publisher_xml – name: John Wiley & Sons, Inc
– name: Nature Publishing Group
References 2002; 359
2010; 10
2012; 111
2013; 2
2012
2013; 21
2006; 368
2013; 45
2007; 120
2008; 171
e_1_2_8_3_1
e_1_2_8_2_1
e_1_2_8_5_1
e_1_2_8_4_1
Rang H.P. (e_1_2_8_10_1) 2012
e_1_2_8_7_1
e_1_2_8_6_1
e_1_2_8_9_1
e_1_2_8_8_1
e_1_2_8_1_1
References_xml – volume: 10
  start-page: 109
  year: 2010
  end-page: 123
  article-title: Molecular determinants of the cardiometabolic phenotype
  publication-title: Endocr. Metab. Immune Disord. Drug Targets
– volume: 368
  start-page: 29
  year: 2006
  end-page: 36
  article-title: Relation between age and cardiovascular disease in men and women with diabetes compared with non‐diabetic people: a population‐based retrospective cohort study
  publication-title: Lancet
– volume: 359
  start-page: 1004
  year: 2002
  end-page: 1010
  article-title: Cardiovascular morbidity and mortality in patients with diabetes in the Losartan Intervention For Endpoint reduction in hypertension study (LIFE): a randomised trial against atenolol
  publication-title: Lancet
– volume: 2
  start-page: e54
  year: 2013
  article-title: The impact of mathematical modelling on the understanding of diabetes and related complications
  publication-title: CPT Pharmacometrics Syst. Pharmacol.
– volume: 21
  start-page: 1025
  year: 2013
  end-page: 1030
  article-title: Development of metabolic syndrome components in adults with a healthy obese phenotype. A three year follow‐up
  publication-title: Obesity (Silver Spring)
– volume: 111
  start-page: 123
  year: 2012
  end-page: 131
  article-title: Pioglitazone and bladder cancer in human studies: is it diabetes itself, diabetes drugs, flawed analyses or different ethnicities?
  publication-title: J. Formos. Med. Assoc.
– start-page: p. 25
  year: 2012
  article-title: The nature of disease and the purpose of therapy
– volume: 171
  start-page: 481
  year: 2008
  end-page: 502
  article-title: Misunderstandings between experimentalists and observationalists about causal inference
  publication-title: J. R. Statist. Soc. A
– volume: 45
  start-page: 52
  year: 2013
  end-page: 59
  article-title: An overview of the genomics of metabolic syndrome
  publication-title: J. Nurs. Scholarsh.
– volume: 120
  start-page: 720
  year: 2007
  end-page: 727
  article-title: Hemoglobin A1c predicts diabetes but not cardiovascular disease in nondiabetic women
  publication-title: Am. J. Med.
– start-page: p. 25
  volume-title: Drug Discovery and Development: Technology in Transition
  year: 2012
  ident: e_1_2_8_10_1
  contributor:
    fullname: Rang H.P.
– ident: e_1_2_8_4_1
  doi: 10.2174/187153010791213119
– ident: e_1_2_8_7_1
  doi: 10.1016/j.jfma.2011.10.003
– ident: e_1_2_8_3_1
  doi: 10.1016/j.amjmed.2007.03.022
– ident: e_1_2_8_9_1
  doi: 10.1038/psp.2013.30
– ident: e_1_2_8_1_1
  doi: 10.1111/j.1547-5069.2012.01484.x
– ident: e_1_2_8_6_1
  doi: 10.1016/S0140-6736(06)68967-8
– ident: e_1_2_8_2_1
  doi: 10.1002/oby.20049
– ident: e_1_2_8_5_1
  doi: 10.1016/S0140-6736(02)08090-X
– ident: e_1_2_8_8_1
  doi: 10.1111/j.1467-985X.2007.00527.x
SSID ssj0000740190
Score 1.9545686
Snippet Despite glycemic control, evidence suggests that mortality and morbidity remain high in diabetes. Regulatory agencies deem, therefore, additional safety trials...
SourceID pubmedcentral
proquest
crossref
pubmed
wiley
SourceType Open Access Repository
Aggregation Database
Index Database
Publisher
StartPage 1
SubjectTerms Biomarkers
Blood pressure
Cardiovascular disease
Diabetes
Glucose
Health risk assessment
Hemoglobin
Homeostasis
Hyperglycemia
Insulin resistance
Lipids
Lipoproteins
Metabolic syndrome
Mortality
SummonAdditionalLinks – databaseName: Health & Medical Collection
  dbid: 7X7
  link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV1Rb9QwDLbG9sILAja2wkBBmvZ0ZZfGuSS8IDQ4TZNgJ7FJ91alqSN46R10e9i_J257dztN2lvVpEpip7Ed258BTuoJOvJSJg5MbI7eUO4qDLlEQpJVOgA15w7_-Dm5uMHLuZ4PF27tEFa5OhO7g7peBL4jP2Nc8qSNuEJ-Wf7NuWoUe1eHEhrPYE_yYGk_m7lZ37GMudycGw9peWNlz5YtY1RK9YnF0UNB9Ei7fBwk-VB57aTP9CW8GNRG8bXn8yvYoeY1nM563On7kbjepFG1I3EqZhtE6vt9KM63ok7Ft94r85k_E1esAoqpDyQWUQwRMu0B3Ey_X59f5EOxhDywkZkrzym2SXxTrB1SpElwIVpKMgoxKl07G6k2uo5B-mQ1UVRVoKLS3gYZHKo3sNssGjoCUTkv6zhOr4uIZK0PPqCtg0ZD0nqZwcmKcuWyx8QoO1-2smUicMkELrXJ4HhF1XL4Mdpyw8YMPq6b05ZmP4VvaHHXJmsEtUuWm3UZHPZMWI_DCofCAjMwW-xZd2C47O2W5s_vDjabsQiVSdMadYx8aurl7NcM-Vmbt0-v4h085359eN8x7N7-u6P3SU25rT50e_E_ip3n1g
  priority: 102
  providerName: ProQuest
– databaseName: Scholars Portal Journals: Open Access
  dbid: M48
  link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV3da9swED-69KUvY93WNVs2NCh5irPKPsXSYIxRWkphI9AE-mZk-UQLxf1IAst_35M_kqVd-yZs2RZ3su530t3vAA6KERqyUrIGRjpCm1JkcnSRREKSOS-AKuQO__4zOp3i2YW62IK2GGcjwNl_XbtQT2p6fz38e7f8yT_8jzplXH-7nQXiSZkMVfoKtmNkFz3E8DU4v1qSQ925ar8lZvwRacbJTa7eo-cDNzCbtARj3DRUT9Dn0yDKf8FtZZ1O3sDrBlaKX_U82IUtKt9Cf1zzUi8HYrJOs5oNRF-M14zVy3cQH21EpYrm1Oa7YHQoqhQt4a3jphftXu17mJ4cT45Oo6aYQuSCExolNqTgsnknXxgkTyNnnNfENgzRJ6ow2lORqsI7admrIp_kjuJcWe2kM5jsQae8KWkfRG6sLPwhX449ktbWWYe6cApTktrKLhy0kstua86MrDrrTnTGss6CrDOVdqHXSjVr9Z4F-nkGnSbmt3xd3eYpH84xbEk3ixl7K6gMe3badOFDrYTVd1rtdSHdUM-qQ6DT3rxTXl1WtNqBqzBJeViDSpEvDT0bn48xtFX68dkhfIKd0KWO_OtBZ36_oM-MYOb5l2p2PgACLexY
  priority: 102
  providerName: Scholars Portal
– databaseName: Wiley-Blackwell Open Access Collection
  dbid: 24P
  link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwlV3da9swEBdb97KXsXZfXrOiQshTvFX2KZb2NtqGUNhmWAN5M7J8Yn1xypw89L_fne04DYXB3oT1YXGnj99Jdz8JMa5mYNEpRRqYmRhchrEtwccKEFCVtABqjh3-_mO2WMLNSq963xyOhen4IYYDN54Z7XrNE9yVTR8mzo7r9w3TTar0s86eixfMGcPU-QnkwxHLBb82156yJIQ6YkPouI_Qoxa-PKp_uCc9AZpP_SUf49h2I5q_Fq96BCm_dSo_Fs-wPhGTvKOgfpjK231EVTOVE5nvyakf3ojk8sABVV51FzRfuZr8yWhQzp1HuQ6yd5Zp3orl_Pr2chH37ybEnu3NOHUcbUs7OYbKAgaceeuDQdquAEKqK2sCVpmugleODCgMaekxKbUzXnkL6TtxVK9r_CBkaZ2qwgV9TgKgMc47D6byGjJUxqlIjHeSK-47eoyivdZOTUECLljAhc4iMdpJtejnSFMw0zzhS5tQK-dDNo1uvrJwNa63DRkmoC0ZccZG4n2nhOE_jD1SSCAS2YF6hgLMnH2YU9_9bhm0mZYwzahb01aR_-p6kf_KgdM6-_h_xU_FS050nn8jcbT5s8VPhGA25Vk7Tv8CXAXrbg
  priority: 102
  providerName: Wiley-Blackwell
Title Cardiovascular Disease: The Other Face of Diabetes
URI https://onlinelibrary.wiley.com/doi/abs/10.1038%2Fpsp.2013.57
https://www.ncbi.nlm.nih.gov/pubmed/24153424
https://www.proquest.com/docview/2290192921
https://search.proquest.com/docview/1445914989
https://pubmed.ncbi.nlm.nih.gov/PMC3817377
Volume 2
hasFullText 1
inHoldings 1
isFullTextHit
isPrint
link http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV3da9swED-a7mUvY9_z2gUNSp_iJLJOkbS3LWtWBunM1kLejCxLrLA6oW4f-t9Pku20obCHvQhj2ZK4O-vufHc_ARxVM1RWU-o5MJMpamFTVaJJKVq0tPQbIA-1w8uz2ekFfl_x1R7wvhYmJu2b8nJc_7ka15e_Y27l5spM-jyxSb6cB1Q5JsRkAAMvoA9c9Lj9hjPm1LSrxZsyOdk0AZiSsjEPR-4FlcUww11F9Mi6fJwk-dB4jdpn8RyedWYj-dwu7wXs2folHOct7vTdiJzfl1E1I3JM8ntE6rtXkM13sk7J1zYq8ym8Rn4EE5AstLFk7UiXIdO8hovFyfn8NO0OS0hNcDJTpkOJrVff1lUKrbMzo4yT1usoRMd4paSzleCVM1R7r8k6VhqblVxLQ41C9gb263Vt3wEplaaVm_rbmUMrpTbaoKwMR2Gp1DSBo55yxabFxChiLJvJwtO6CLQuuEjgsKdq0X0YTRHg5b1RqTI_ysdttxfpEKfQtV3fNt4bQa685yZVAm9bJmzn6bmXgNhhz_aBAJe92-OlKMJmd1KTwCgy8l9LL_JfOYZrLt7_90QH8DQM0Wb-HcL-zfWt_eAtmJtyCIMMc9-KlRjCky8nZ_nPYfwb4NtvK-rbJcphlOu_Lu727g
link.rule.ids 230,315,730,783,787,867,888,2228,11574,12068,21400,24330,27936,27937,31731,31732,33756,33757,43322,43817,46064,46488,50826,50935,53804,53806,74073,74630
linkProvider National Library of Medicine
linkToHtml http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV3Nb9MwFH8a2wEuiG8CA4w07dSwOrYbmwvaxqoOthJBJ-1mOc6z4JIWsh323-OXpO2qSbtFcaw47zl-378HsFeNpEHHeeTASKfS5ZiaUvqUS5TIy3gAKqodPp-OJhfy26W67B1uTZ9WuTwT24O6mnvykR8QLnnURkzGvyz-ptQ1iqKrfQuNB7BDUFXR-No5OpkWP1deliE1nDPDvjBvKPTBoiGUSi4-kUC6LYru6Jd30yRvq6-t_Bk_gce94sgOO04_hS2sn8F-0SFP3wzYbF1I1QzYPivWmNQ3zyE73sg7ZV-7uMxnmsZ-kBLIxs4jmwfW58g0L-BifDI7nqR9u4TUk5mZCkdFtlGAY6iMxIAjb3zQGKWUlEGoyuiAVa6q4LmLdhMGUXrMSuW0595I8RK263mNr4GVxvEqDOPtLEjU2nnnpa68kjly7XgCe0vK2UWHimHbaLbQNhLYEoGtyhPYXVLV9r9GY9eMTODjajhuaopUuBrn1020R6Qy0XbTJoFXHRNW7yGVQ8hMJpBvsGf1AAFmb47Uf363wNm0RUQelzVoGXnf0m3xq5B0rfI393_FB3g4mZ2f2bPT6fe38IjmdMl-u7B99e8a30Wl5ap83-_M_45S7Cw
linkToPdf http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV1Lb9QwEB7BVkJcEOXVQClGqnrasHFsJzYX1NeqvJYIWqk3y3FswSW7kPbQf48n8e52Vam3KI4VZ2bimfHMfAOw3xRcOUNp4EAhU25Kl6qa25Ryxx2twwYosHb4-6w4u-BfLsVlzH_qYlrlck_sN-pmbvGMfIK45MEaUTmd-JgWUZ1MPy3-pthBCiOtsZ3GQ9gqecGyEWwdnc6qn6sTlwybz6ksFullTE4WHSJWUvYBldNttXTH1rybMnnblO110fQpPIlGJDkcuL4ND1z7DA6qAYX6ZkzO10VV3ZgckGqNT33zHPLjjRxUcjLEaD7iNPIDDUIyNdaRuScxX6Z7ARfT0_PjszS2TkgtupwpM1hwG5S5843izrvCKuulCxqLc89Eo6R3TSkab6kJPpTzrLYur4WRllrF2UsYtfPW7QCplaGNz8Lt3HMnpbHGctlYwUtHpaEJ7C8ppxcDQobuI9tM6kBgjQTWokxgd0lVHX-TTq-ZmsD71XAQcIxamNbNr7vgm3Chgh8nVQKvBias3oPmB-M5T6DcYM_qAQTP3hxp__zuQbQRmZCVYVnjnpH3LV1XvyqO16J8ff9XvINHQSj1t8-zr2_gMU4Z8v52YXT179q9DfbLVb0XBfM_bU7wWg
openUrl ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Cardiovascular+disease%3A+the+other+face+of+diabetes&rft.jtitle=CPT%3A+pharmacometrics+and+systems+pharmacology&rft.au=Vlasakakis%2C+G&rft.au=Della+Pasqua%2C+O&rft.date=2013-10-01&rft.issn=2163-8306&rft.eissn=2163-8306&rft.volume=2&rft.spage=e81&rft_id=info:doi/10.1038%2Fpsp.2013.57&rft_id=info%3Apmid%2F24153424&rft.externalDocID=24153424
thumbnail_l http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=2163-8306&client=summon
thumbnail_m http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=2163-8306&client=summon
thumbnail_s http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=2163-8306&client=summon