Synthetic Studies towards CH‐Diazomethane Sulfonamides: a Novel Type of Diazo Reagents

• Published in: European journal of organic chemistry Vol. 2020; no. 27; pp. 4112 - 4115
• Main Authors: Bubyrev, Andrey, Dar'in, Dmitry, Kantin, Grigory, Krasavin, Mikhail
• Format: Journal Article
• Language: English
• Published: WEINHEIM Wiley 23.07.2020; Wiley Subscription Services, Inc
• Subjects: Alkynes; Chemistry; Chemistry, Organic; Cycloaddition; Deacetylation; Diazomethane; Diazomethane sulfonamides; Physical Sciences; Pyrazole; Reagents; SAFE diazo transfer; Science & Technology; Styrenes; Sulfonamides; SAFE diazo transfer; Cycloaddition; Diazomethane sulfonamides; Deacetylation; ALPHA-DIAZOPHOSPHONIC ACIDS; Alkynes

Preparation of CH‐diazomethane sulfonamides has been developed for the first time. Their utility as a new type of diazo reagents was showcased in cycloaddition reactions with electron‐deficient alkynes and β‐nitro styrenes which delivered medicinally important pyrazole‐3‐sulfonamides in good to exce...